Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.50 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.44 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.44 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.44 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.44 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.44 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7453660 | 0.91 | RXFP1 (0.48) | RXFP1L3MBTL1PTGS1PTGS2MAPT | |
| SCHEMBL7449744 | 0.90 | PTGS1 (0.49) | RXFP1L3MBTL1PTGS1PTGS2MAPT | |
| SCHEMBL7451575 | 0.90 | PTGS1 (0.49) | RXFP1L3MBTL1PTGS1PTGS2MAPT | |
| SCHEMBL7454713 | 0.89 | MAPT (0.62) | RXFP1PTGS1PTGS2MAPTTHRB | |
| SCHEMBL7461317 | 0.88 | PTGS1 (0.43) | RXFP1L3MBTL1PTGS1PTGS2MAPT | |
| SCHEMBL7452400 | 0.88 | SMN1; SMN2 (0.64) | RXFP1PTGS1PTGS2MAPTTHRB | |
| SCHEMBL7453020 | 0.86 | PTGS1 (0.50) | RXFP1PTGS1PTGS2MAPTTHRB | |
| SCHEMBL7458444 | 0.85 | RXFP1 (0.46) | RXFP1L3MBTL1MAPTTHRBTSHR | |
| SCHEMBL7450997 | 0.84 | RXFP1 (0.48) | RXFP1L3MBTL1PTGS1PTGS2MAPT | |
| SCHEMBL7456044 | 0.84 | PTGS1 (0.48) | RXFP1PTGS1PTGS2MAPTTHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002081474-A1 | TRIAZOLOPHTHALAZINE / QUINOLINE / ISOQUINOLINE DERIVATIVES WHICH ARE LIGANDS FOR GABA-A RECEPTORS CONTAINING THE ALPHA 5 SUBTYPE | MERCK SHARP & DOHME LIMITED (GB) | 2002-10-17 | — | — | WO | claimed |
| WO-2002081474-A1 | TRIAZOLOPHTHALAZINE / QUINOLINE / ISOQUINOLINE DERIVATIVES WHICH ARE LIGANDS FOR GABA-A RECEPTORS CONTAINING THE ALPHA 5 SUBTYPE | MERCK SHARP & DOHME LIMITED (GB) | 2002-10-17 | — | — | WO | disclosed |