SCHEMBL7449206

SCHEMBL7449206

COc1nc(NCCCO)nc(N[C@@H](Cc2ccc(NC(=O)c3c(Cl)cncc3Cl)cc2)C(=O)O)n1

nearest known ligand 0.91

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
ITGB1 P05556 20/20 0.91
ITGA4 P13612 20/20 0.91

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5364460 0.95 ITGB1 (1.00) ITGB1ITGA4
SCHEMBL5368089 0.92 ITGB1 (1.00) ITGB1ITGA4
SCHEMBL5367895 0.90 ITGB1 (1.00) ITGB1ITGA4
SCHEMBL5366263 0.90 ITGB1 (1.00) ITGB1ITGA4
SCHEMBL6109444 0.90 ITGB1 (1.00) ITGB1ITGA4
SCHEMBL5358518 0.87 ITGB1 (0.91) ITGB1ITGA4
SCHEMBL5367906 0.84 ITGB1 (1.00) ITGB1ITGA4
SCHEMBL5362586 0.84 ITGB1 (1.00) ITGB1ITGA4
SCHEMBL5370402 0.83 ITGB1 (1.00) ITGB1ITGA4
SCHEMBL5367803 0.83 ITGB1 (1.00) ITGB1ITGA4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6348463-B1 Phenylalanine derivatives CELLTECH THERAPEUTICS LIMITED (GB) 2002-02-19 US claimed
EP-1117657-A1 PHENYLALANINE DERIVATIVES AS ALPHA 4 INTEGRIN INHIBITORS CELLTECH THERAPEUTICS LIMITED (GB) 2001-07-25 EP claimed
WO-2000018759-A1 PHENYLALANINE DERIVATIVES AS ALPHA 4 INTEGRIN INHIBITORS CELLTECH THERAPEUTICS LIMITED (GB) 2000-04-06 WO claimed
US-6348463-B1 Phenylalanine derivatives CELLTECH THERAPEUTICS LIMITED (GB) 2002-02-19 US disclosed