Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 11/20 | 0.59 |
| ▸ | PLAT | P00750 | 5/20 | 0.38 |
| ▸ | PLG | P00747 | 7/20 | 0.38 |
| ▸ | CTSS | P25774 | 1/20 | 0.34 |
| ▸ | CTSK | P43235 | 1/20 | 0.34 |
| ▸ | ADAM17 | P78536 | 3/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.30 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.30 |
| ▸ | MMP1 | P03956 | 1/20 | 0.30 |
| ▸ | MMP13 | P45452 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7642304 | 0.91 | PLAU (0.48) | PLAUPLATPLGCTSSCTSK | |
| Hydrochloric Acid SCHEMBL7450206 | 0.90 | PLAU (0.47) | PLAUPLATPLGCTSSCTSK | |
| Hydrochloric Acid SCHEMBL6439003 | 0.90 | PLAU (0.47) | PLAUPLATPLGCTSSCTSK | |
| SCHEMBL6976393 | 0.90 | PLAU (0.47) | PLAUPLATPLGCTSSCTSK | |
| Hydrochloric Acid SCHEMBL7375441 | 0.89 | PLAU (0.47) | PLAUPLATPLGCTSSCTSK | |
| SCHEMBL6432812 | 0.85 | PLAU (0.41) | PLAUPLATPLGADAM17USP2 | |
| Hydrochloric Acid SCHEMBL6433002 | 0.84 | PLAU (0.42) | PLAUPLATPLGADAM17USP2 | |
| Hydrochloric Acid SCHEMBL6433882 | 0.84 | PLAU (0.41) | PLAUPLATPLGADAM17USP2 | |
| SCHEMBL6438599 | 0.84 | PLAU (0.52) | PLAUPLATPLGADAM17USP2 | |
| SCHEMBL7449730 | 0.83 | PLAU (0.60) | PLAUPLATPLGCTSSCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1242120-A2 | COMBINATIONS OF GROWTH FACTORS AND I:UPA OR I:MMP FOR THE TREATMENT OF DAMAGED TISSUE | Pfizer Limited (GB) | 2002-09-25 | — | — | EP | disclosed |
| WO-2001049309-A2 | COMBINATIONS OF GROWTH FACTORS AND I: UPA OR I: MMP FOR THE TREATMENT OF DAMAGED TISSUE | PFIZER LIMITED (GB) | 2001-07-12 | — | — | WO | disclosed |
| EP-1077945-A1 | ISOQUINOLINES AS UROKINASE INHIBITORS | PFIZER INC. (US) | 2001-02-28 | — | — | EP | disclosed |
| WO-2000005214-A2 | ISOQUINOLINES AS UROKINASE INHIBITORS | PFIZER INC. (US) | 2000-02-03 | — | — | WO | disclosed |