Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | MDM2 | Q00987 | 8/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | PDE5A | O76074 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | RECQL | P46063 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7449932 | 1.00 | TSHR (0.46) | TSHRMAPK1TP53HSD17B10HPGD | |
| SCHEMBL7446930 | 0.98 | TSHR (0.44) | TSHRMAPK1TP53HSD17B10HPGD | |
| SCHEMBL7446937 | 0.98 | TSHR (0.44) | TSHRMAPK1TP53HSD17B10HPGD | |
| SCHEMBL7436704 | 0.91 | MAPK1 (0.48) | TSHRMAPK1TP53HSD17B10HPGD | |
| SCHEMBL7436693 | 0.91 | MAPK1 (0.48) | TSHRMAPK1TP53HSD17B10HPGD | |
| SCHEMBL7449228 | 0.90 | TSHR (0.49) | TSHRMAPK1TP53HSD17B10HPGD | |
| SCHEMBL7449225 | 0.90 | TSHR (0.49) | TSHRMAPK1TP53HSD17B10HPGD | |
| SCHEMBL7440766 | 0.89 | MAPK1 (0.46) | TSHRMAPK1TP53HSD17B10HPGD | |
| SCHEMBL7446214 | 0.89 | MAPK1 (0.46) | TSHRMAPK1TP53HSD17B10HPGD | |
| SCHEMBL7431286 | 0.89 | MAPK1 (0.46) | TSHRMAPK1TP53HSD17B10HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0538332-B1 | POLYCYCLIC GUANINE DERIVATIVES | SCHERING CORP (US) | 1997-07-23 | — | — | EP | disclosed |
| US-5393755-A | Hypotensive agents, enzyme inhibitors | SCHERING CORPORATION (US) | 1995-02-28 | — | — | US | disclosed |
| EP-0538332-A1 | POLYCYCLIC GUANINE DERIVATIVES. | SCHERING CORP (US) | 1993-04-28 | — | — | EP | disclosed |
| WO-1991019717-A1 | POLYCYCLIC GUANINE DERIVATIVES | SCHERING CORPORATION (US) | 1991-12-26 | — | — | WO | disclosed |