Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 20/20 | 0.58 |
| ▸ | PDE4A | P27815 | 16/20 | 0.58 |
| ▸ | PDE4C | Q08493 | 16/20 | 0.58 |
| ▸ | PDE4D | Q08499 | 16/20 | 0.58 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6197797 | 0.99 | PDE4B (0.59) | PDE4BPDE4APDE4CPDE4DABCB11 | |
| SCHEMBL6196611 | 0.99 | PDE4B (0.59) | PDE4BPDE4APDE4CPDE4DABCB11 | |
| SCHEMBL6196613 | 0.99 | PDE4B (0.59) | PDE4BPDE4APDE4CPDE4DABCB11 | |
| SCHEMBL7451195 | 0.89 | PDE4B (0.50) | PDE4BPDE4APDE4CPDE4DABCB11 | |
| SCHEMBL6196516 | 0.89 | PDE4B (0.63) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL6545778 | 0.89 | PDE4B (0.63) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL6196511 | 0.89 | PDE4B (0.63) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL6199802 | 0.89 | PDE4B (0.55) | PDE4BPDE4APDE4CPDE4DABCB11 | |
| SCHEMBL6197472 | 0.89 | PDE4B (0.55) | PDE4BPDE4APDE4CPDE4DABCB11 | |
| SCHEMBL5799817 | 0.89 | PDE4B (0.55) | PDE4BPDE4APDE4CPDE4DABCB11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1043994-A4 | METHOD FOR TREATING MULTIPLE SCLEROSIS | SMITHKLINE BEECHAM CORP (US) | 2002-09-11 | — | — | EP | claimed |
| EP-1043994-A1 | METHOD FOR TREATING MULTIPLE SCLEROSIS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-10-18 | — | — | EP | claimed |
| WO-1999034797-A1 | METHOD FOR TREATING MULTIPLE SCLEROSIS | SMITHKLINE BEECHAM CORPORATION (US) | 1999-07-15 | — | — | WO | claimed |