Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 9/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7456805 | 1.00 | SMN1; SMN2 (0.48) | SMN1; SMN2L3MBTL1MCL1KMT2AMEN1 | |
| SCHEMBL7518718 | 0.77 | MCL1 (0.48) | SMN1; SMN2L3MBTL1MCL1KMT2AMEN1 | |
| SCHEMBL15401829 | 0.77 | MCL1 (0.48) | SMN1; SMN2L3MBTL1MCL1KMT2AMEN1 | |
| SCHEMBL15401859 | 0.77 | MCL1 (0.48) | SMN1; SMN2L3MBTL1MCL1KMT2AMEN1 | |
| SCHEMBL15402538 | 0.76 | HPGD (0.47) | SMN1; SMN2L3MBTL1MCL1KMT2AMEN1 | |
| SCHEMBL4812101 | 0.68 | SMN1; SMN2 (0.64) | SMN1; SMN2L3MBTL1MCL1KMT2AMEN1 | |
| SCHEMBL30223215 | 0.68 | SMN1; SMN2 (0.64) | SMN1; SMN2L3MBTL1MCL1KMT2AMEN1 | |
| SCHEMBL30223355 | 0.68 | SMN1; SMN2 (0.64) | SMN1; SMN2L3MBTL1MCL1KMT2AMEN1 | |
| SCHEMBL17788542 | 0.67 | HPGD (0.69) | SMN1; SMN2L3MBTL1MCL1KMT2AMEN1 | |
| Hydrochloric Acid SCHEMBL7513039 | 0.67 | MCL1 (0.58) | SMN1; SMN2L3MBTL1MCL1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2580207-A1 | NITROGEN CONTAINING HETEROARYL COMPOUNDS | F. Hoffmann-La Roche AG (CH) | 2013-04-17 | — | — | EP | disclosed |
| WO-2011154327-A1 | NITROGEN CONTAINING HETEROARYL COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2011-12-15 | — | — | WO | disclosed |