SCHEMBL7455591

SCHEMBL7455591

O=C1NC(=O)C(Cc2ccc(OCc3nc(-c4ccccc4)cs3)cc2)S1

nearest known ligand 0.63

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
FFAR1 O14842 13/20 0.63
PPARG P37231 9/20 0.55
PPARA Q07869 6/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1299621 0.81 FFAR1 (0.83) FFAR1PPARGPPARA
SCHEMBL1848104 0.81 PPARG (0.69) FFAR1PPARGPPARA
SCHEMBL1299855 0.80 FFAR1 (0.80) FFAR1PPARGPPARA
SCHEMBL7455599 0.80 PPARD (0.44) FFAR1PPARA
SCHEMBL7836277 0.78 PPARG (0.70) FFAR1PPARGPPARA
SCHEMBL1746645 0.78 FFAR1 (1.00) FFAR1PPARGPPARA
SCHEMBL8314978 0.78 FFAR1 (0.70) FFAR1PPARGPPARA
SCHEMBL1072226 0.77 FFAR1 (0.77) FFAR1PPARGPPARA
SCHEMBL8312136 0.77 FFAR1 (0.87) FFAR1PPARGPPARA
SCHEMBL7454600 0.77 FFAR1 (0.62) FFAR1PPARGPPARA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1999059586-A1 THIAZOLIDINE AND OXAZOLIDINE DERIVATIVES FOR THE TREATMENT OF ACUTE MYOCARDIAL INFARCTION AND INHIBITION OF CARDIOMYOCYTE APOPTOSIS REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 1999-11-25 WO claimed
EP-0804193-A4 THIAZOLIDINE DERIVATIVES FOR THE TREATMENT OF PSORIASIS KURTZ THEODORE W (US) 2002-03-27 EP disclosed
US-6110951-A LOWERING INSULIN DRUG THERAPY IN NON-OBESE, NON-DIABETIC INDIVIDUALS BETHESDA PHARMACEUTICALS, INC. 2000-08-29 US disclosed
WO-1999059586-A1 THIAZOLIDINE AND OXAZOLIDINE DERIVATIVES FOR THE TREATMENT OF ACUTE MYOCARDIAL INFARCTION AND INHIBITION OF CARDIOMYOCYTE APOPTOSIS REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 1999-11-25 WO disclosed
EP-0804193-A1 THIAZOLIDINE DERIVATIVES FOR THE TREATMENT OF PSORIASIS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 1997-11-05 EP disclosed
US-5594015-A Thiazolidine derivatives for the treatment of psoriasis REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 1997-01-14 US disclosed
WO-1995035108-A1 THIAZOLIDINE DERIVATIVES FOR THE TREATMENT OF PSORIASIS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 1995-12-28 WO disclosed
US-5053420-A Antidiabetic agents KURTZ, THEODORE W. 1991-10-01 US disclosed
EP-0208420-B1 THIAZOLIDINE DERIVATIVES, THEIR PRODUCTION AND USE Takeda Chemical Industries, Ltd. (JP) 1991-09-18 EP disclosed
WO-1991005538-A2 THIAZOLIDINE DERIVATIVES FOR THE TREATMENT OF HYPERTENSION PERSHADSINGH HARRIHAR A (US) 1991-05-02 WO disclosed
US-4775687-A ANTIDIABETIC AGENTS TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1988-10-04 US disclosed
EP-0208420-A1 Thiazolidine derivatives, their production and use Takeda Chemical Industries, Ltd. (JP) 1987-01-14 EP disclosed