Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.59 |
| ▸ | RAB9A | P51151 | 3/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.47 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.47 |
| ▸ | TLR4 | O00206 | 1/20 | 0.47 |
| ▸ | TLR2 | O60603 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14966277 | 0.86 | MAPT (0.64) | MAPTRAB9ASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL19313609 | 0.84 | GPBAR1 (0.58) | MAPTCYSLTR1KDM4EGPBAR1PARP10 | |
| SCHEMBL28413229 | 0.84 | CYSLTR1 (0.53) | MAPTRAB9ASMN1; SMN2KMT2ACYSLTR1 | |
| SCHEMBL7454446 | 0.84 | MRGPRX4 (0.64) | MAPTRAB9AKMT2AMEN1CYSLTR1 | |
| SCHEMBL1439028 | 0.83 | MAPK1 (0.59) | MAPTRAB9AKMT2AMEN1MAPK1 | |
| SCHEMBL12020460 | 0.82 | GRM5 (0.57) | MAPTRAB9ASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL4550597 | 0.82 | KMT2A (0.50) | MAPTSMN1; SMN2KMT2AMEN1MAPK1 | |
| SCHEMBL9989631 | 0.82 | MRGPRX4 (0.48) | MAPTRAB9ASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL12020428 | 0.81 | HPGD (0.56) | RAB9ASMN1; SMN2KMT2AMEN1NPC1 | |
| SCHEMBL17664420 | 0.81 | MAPK1 (0.54) | MAPTRAB9ASMN1; SMN2KMT2AMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8969389-B2 | Substituted 6-methylnicotinamides as mGluR5 positive allosteric modulators | VANDERBILT UNIVERSITY (US) | 2015-03-03 | — | — | US | disclosed |
| US-8969389-B2 | Substituted 6-methylnicotinamides as mGluR5 positive allosteric modulators | VANDERBILT UNIVERSITY (US) | 2015-03-03 | — | — | US | disclosed |
| US-8969389-B2 | Substituted 6-methylnicotinamides as mGluR5 positive allosteric modulators | VANDERBILT UNIVERSITY (US) | 2015-03-03 | — | — | US | disclosed |
| EP-2575461-A1 | SUBSTITUTED-6-METHYLNICOTINAMIDES AS MGLUR5 POSITIVE ALLOSTERIC MODULATORS | Vanderbilt University (US) | 2013-04-10 | — | — | EP | disclosed |
| US-20110294858-A1 | SUBSTITUTED 6-METHYLNICOTINAMIDES AS MGLUR5 POSITIVE ALLOSTERIC MODULATORS | NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 2011-12-01 | — | — | US | disclosed |
| US-20110294858-A1 | SUBSTITUTED 6-METHYLNICOTINAMIDES AS MGLUR5 POSITIVE ALLOSTERIC MODULATORS | NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 2011-12-01 | — | — | US | disclosed |
| US-20110294858-A1 | SUBSTITUTED 6-METHYLNICOTINAMIDES AS MGLUR5 POSITIVE ALLOSTERIC MODULATORS | NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 2011-12-01 | — | — | US | disclosed |
| WO-2011149963-A1 | SUBSTITUTED-6-METHYLNICOTINAMIDES AS MGLUR5 POSITIVE ALLOSTERIC MODULATORS | VANDERBILT UNIVERSITY (US) | 2011-12-01 | — | — | WO | disclosed |
| WO-2011149963-A1 | SUBSTITUTED-6-METHYLNICOTINAMIDES AS MGLUR5 POSITIVE ALLOSTERIC MODULATORS | VANDERBILT UNIVERSITY (US) | 2011-12-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110294858-A1 | SUBSTITUTED 6-METHYLNICOTINAMIDES AS MGLUR5 POSITIVE ALLOSTERIC MODULATORS | GRM5, GRIK5, GRM6 | MAPT 270/4885RAB9A 2376/4885SMN1; SMN2 1172/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.