Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.51 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.50 |
| ▸ | PLA2G5 | P39877 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11270312 | 0.81 | GAA (0.74) | GAAPOLBHDAC1HDAC6PLA2G10 | |
| SCHEMBL13687172 | 0.80 | GAA (0.59) | GAAPOLBHDAC1HDAC6PLA2G10 | |
| SCHEMBL5181865 | 0.77 | GAA (0.56) | GAAPOLBHDAC1HDAC6PLA2G10 | |
| SCHEMBL8728068 | 0.76 | GAA (0.55) | GAAPOLBHDAC1HDAC6PLA2G10 | |
| SCHEMBL8726366 | 0.75 | PLA2G10 (0.56) | GAAPOLBHDAC1HDAC6PLA2G10 | |
| SCHEMBL20516432 | 0.74 | GAA (0.49) | GAAPOLBHDAC1HDAC6PLA2G10 | |
| SCHEMBL20516433 | 0.74 | GAA (0.49) | GAAPOLBHDAC1HDAC6PLA2G10 | |
| SCHEMBL13879515 | 0.74 | HDAC1 (0.69) | GAAPOLBHDAC1HDAC6PLA2G10 | |
| SCHEMBL6641053 | 0.74 | GAA (0.63) | GAAPOLBHDAC1HDAC6PLA2G10 | |
| SCHEMBL11484748 | 0.72 | GAA (0.51) | GAAPOLBHDAC1HDAC6PLA2G10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0718290-B1 | Carboxyalkyl heterocyclic derivatives | NIPPON ZOKI PHARMACEUTICAL CO (JP) | 2002-04-17 | — | — | EP | disclosed |
| US-5912261-A | ANTIDIABETIC AGENTS | NIPPON ZOKI PHARMACEUTICAL CO., LTD. (JP) | 1999-06-15 | — | — | US | disclosed |
| EP-0718290-A1 | Carboxyalkyl heterocyclic derivatives | NIPPON ZOKI PHARMACEUTICAL CO., LTD. (JP) | 1996-06-26 | — | — | EP | disclosed |