Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 18/20 | 0.36 |
| ▸ | PPARA | Q07869 | 15/20 | 0.36 |
| ▸ | PPARD | Q03181 | 14/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.34 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7663359 | 0.92 | PPARG (0.36) | PPARGPPARAPPARDNR1H2NR1H3 | |
| SCHEMBL7663378 | 0.90 | PPARG (0.37) | PPARGPPARAPPARDNR1H2 | |
| SCHEMBL7531877 | 0.84 | PPARG (0.38) | PPARGPPARAPPARDMEN1CYP1A2 | |
| SCHEMBL7664139 | 0.84 | PPARG (0.37) | PPARGPPARAPPARDNR1H2 | |
| SCHEMBL5209077 | 0.82 | PPARG (0.57) | PPARGPPARAPPARD | |
| SCHEMBL7657026 | 0.79 | PPARA (0.51) | PPARGPPARAPPARDNR1H2NR1H3 | |
| SCHEMBL5209899 | 0.76 | PPARG (0.59) | PPARGPPARAPPARD | |
| SCHEMBL7523011 | 0.76 | PPARG (0.38) | PPARGPPARAPPARDNR1H2NR1H3 | |
| SCHEMBL7461206 | 0.74 | PPARG (0.39) | PPARGPPARAPPARDNR1H2 | |
| SCHEMBL7466079 | 0.74 | PPARA (0.65) | PPARGPPARAPPARD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6399640-B1 | ANTIDIABETIC AGENTS; ANTICHOLESTEROL AGENTS | MERCK & CO., INC. | 2002-06-04 | — | — | US | claimed |
| EP-1194146-A4 | ARYLTHIAZOLIDINEDIONE AND ARYLOXAZOLIDINEDIONE DERIVATIVES | MERCK & CO INC (US) | 2002-07-31 | — | — | EP | disclosed |
| US-6399640-B1 | ANTIDIABETIC AGENTS; ANTICHOLESTEROL AGENTS | MERCK & CO., INC. | 2002-06-04 | — | — | US | disclosed |
| EP-1194146-A1 | ARYLTHIAZOLIDINEDIONE AND ARYLOXAZOLIDINEDIONE DERIVATIVES | Merck & Co., Inc. (US) | 2002-04-10 | — | — | EP | disclosed |
| WO-2000078312-A1 | ARYLTHIAZOLIDINEDIONE AND ARYLOXAZOLIDINEDIONE DERIVATIVES | MERCK & CO., INC. (US) | 2000-12-28 | — | — | WO | disclosed |