Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 14/20 | 0.40 |
| ▸ | PPARD | Q03181 | 11/20 | 0.40 |
| ▸ | PPARA | Q07869 | 11/20 | 0.40 |
| ▸ | NR1H2 | P55055 | 5/20 | 0.39 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.37 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7663361 | 0.92 | PPARG (0.40) | PPARGPPARDPPARANR1H2GRM2 | |
| SCHEMBL7454425 | 0.89 | PPARG (0.43) | PPARGPPARDPPARANR1H2 | |
| SCHEMBL5208431 | 0.81 | PPARG (0.57) | PPARGPPARDPPARA | |
| SCHEMBL7468050 | 0.81 | PPARG (0.53) | PPARGPPARDPPARANR1H2NR1H3 | |
| SCHEMBL7464894 | 0.80 | PPARG (0.42) | PPARGPPARDPPARANR1H2 | |
| SCHEMBL7458629 | 0.77 | PPARA (0.49) | PPARGPPARDPPARAGRM2 | |
| SCHEMBL7663368 | 0.77 | PPARA (0.40) | PPARGPPARDPPARANR1H2GRM2 | |
| SCHEMBL7461206 | 0.76 | PPARG (0.39) | PPARGPPARDPPARANR1H2 | |
| SCHEMBL5208436 | 0.76 | PPARA (0.41) | PPARGPPARDPPARANR1H2GRM2 | |
| SCHEMBL7670010 | 0.75 | PPARA (0.40) | PPARGPPARDPPARANR1H2GRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6399640-B1 | ANTIDIABETIC AGENTS; ANTICHOLESTEROL AGENTS | MERCK & CO., INC. | 2002-06-04 | — | — | US | claimed |
| EP-1194146-A4 | ARYLTHIAZOLIDINEDIONE AND ARYLOXAZOLIDINEDIONE DERIVATIVES | MERCK & CO INC (US) | 2002-07-31 | — | — | EP | disclosed |
| US-6399640-B1 | ANTIDIABETIC AGENTS; ANTICHOLESTEROL AGENTS | MERCK & CO., INC. | 2002-06-04 | — | — | US | disclosed |
| EP-1194146-A1 | ARYLTHIAZOLIDINEDIONE AND ARYLOXAZOLIDINEDIONE DERIVATIVES | Merck & Co., Inc. (US) | 2002-04-10 | — | — | EP | disclosed |
| WO-2000078312-A1 | ARYLTHIAZOLIDINEDIONE AND ARYLOXAZOLIDINEDIONE DERIVATIVES | MERCK & CO., INC. (US) | 2000-12-28 | — | — | WO | disclosed |