Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 2/20 | 0.71 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.71 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.71 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.71 |
| ▸ | GSK3B | P49841 | 3/20 | 0.67 |
| ▸ | CDC7 | O00311 | 1/20 | 0.67 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.67 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.67 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.67 |
| ▸ | PHKG2 | P15735 | 1/20 | 0.67 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.67 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.67 |
| ▸ | CLK2 | P49760 | 1/20 | 0.67 |
| ▸ | GSK3A | P49840 | 1/20 | 0.67 |
| ▸ | NEK4 | P51957 | 1/20 | 0.67 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.67 |
| ▸ | CSNK1G2 | P78368 | 1/20 | 0.67 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.67 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.67 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7459355 | 1.00 | PIM1 (0.71) | PIM1PIM3PIM2PDE4BGSK3B | |
| SCHEMBL7457209 | 0.90 | PIM1 (0.71) | PIM1PIM3PIM2PDE4BGSK3B | |
| SCHEMBL7457214 | 0.90 | PIM1 (0.71) | PIM1PIM3PIM2PDE4BGSK3B | |
| SCHEMBL31521577 | 0.84 | PDE4B (1.00) | PIM1PIM3PIM2PDE4BGSK3B | |
| SCHEMBL2424653 | 0.84 | PDE4B (1.00) | PIM1PIM3PIM2PDE4BGSK3B | |
| SCHEMBL2424658 | 0.84 | PDE4B (1.00) | PIM1PIM3PIM2PDE4BGSK3B | |
| SCHEMBL15421515 | 0.84 | PDE4B (1.00) | PIM1PIM3PIM2PDE4BGSK3B | |
| SCHEMBL1249095 | 0.83 | PIM1 (0.77) | PIM1PIM3PIM2PDE4BGSK3B | |
| SCHEMBL15421753 | 0.83 | PIM1 (0.80) | PIM1PIM3PIM2PDE4BGSK3B | |
| SCHEMBL15421752 | 0.83 | PIM1 (0.80) | PIM1PIM3PIM2PDE4BGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0846693-B1 | N-BENZYLDIOXOTHIAZOLIDYLBENZAMIDE DERIVATIVES AND PROCESS FOR PRODUCING THE SAME | KYORIN SEIYAKU KK (JP) | 2002-01-23 | — | — | EP | disclosed |
| US-6147101-A | TREATING HYPERGLYCEMIA | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 2000-11-14 | — | — | US | disclosed |
| US-6030990-A | ANTIDIABETIC AND -LIPEMIC AGENTS; PARTICULARLY FOR NON-INSULIN DEPENDENT DIABETES MELLITUS, A BLOOD SUGAR-LOWERING DRUG THAT IMPROVES THE INSULIN RESISTANCE AND HAS HIGH SAFETY AND EFFICIENCY | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 2000-02-29 | — | — | US | disclosed |
| US-6001862-A | ADMINISTERING TO A PATIENT SUFFERING FROM NON-INSULIN DEPENDENT DIABETES MELLITUS A N-BENZYLDIOXOTHIAZOLIDYLBENZAMIDE COMPOUND | KYORIN PHARAMEUTICALS CO., LTD. (JP) | 1999-12-14 | — | — | US | disclosed |
| EP-0846693-A1 | N-BENZYLDIOXOTHIAZOLIDYLBENZAMIDE DERIVATIVES AND PROCESS FOR PRODUCING THE SAME | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 1998-06-10 | — | — | EP | disclosed |