Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADA | P00813 | 4/20 | 0.69 |
| ▸ | PDE2A | O00408 | 3/20 | 0.69 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.69 |
| ▸ | PDE4A | P27815 | 1/20 | 0.69 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.69 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.69 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.69 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.69 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.69 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.69 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.69 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.69 |
| ▸ | TSHR | P16473 | 1/20 | 0.69 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.69 |
| ▸ | LMNA | P02545 | 1/20 | 0.67 |
| ▸ | BLM | P54132 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7458479 | 0.97 | ADA (0.71) | ADAPDE2ACYP3A4PDE4APDE4B | |
| SCHEMBL7458088 | 0.96 | ADA (0.72) | ADAPDE2ACYP3A4PDE4APDE4B | |
| SCHEMBL7456900 | 0.93 | — | — | |
| Hydrochloric Acid SCHEMBL1740511 | 0.92 | — | — | |
| SCHEMBL8577504 | 0.86 | ADA (0.65) | ADAPDE2ACYP3A4PDE4APDE4B | |
| SCHEMBL7458391 | 0.86 | ADA (0.65) | ADAPDE2ACYP3A4PDE4APDE4B | |
| SCHEMBL7452717 | 0.85 | ADA (0.50) | ADAPDE2ACYP3A4PDE4APDE4B | |
| SCHEMBL8585199 | 0.83 | ADA (0.82) | ADAPDE2ACYP3A4PDE4APDE4B | |
| SCHEMBL16395274 | 0.83 | ADA (0.67) | ADAPDE2ACYP3A4PDE4APDE4B | |
| SCHEMBL15270317 | 0.83 | ADA (0.67) | ADAPDE2ACYP3A4PDE4APDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0936911-B1 | ADENOSINE DEAMINASE INHIBITORS | RHODE ISLAND EDUCATION (US) | 2002-04-10 | — | — | EP | disclosed |
| EP-0936911-A4 | — | — | 1999-10-06 | — | — | EP | disclosed |
| EP-0936911-A1 | ADENOSINE DEAMINASE INHIBITORS | THE BOARD OF GOVERNORS FOR HIGHER EDUCATION STATE OF RHODE ISLAND AND PROVIDENCE PLANTATIONS (US) | 1999-08-25 | — | — | EP | disclosed |
| WO-1998002166-A1 | ADENOSINE DEAMINASE INHIBITORS | THE BOARD OF GOVERNORS FOR HIGHER EDUCATION, STATE OF RHODE ISLAND AND PROVIDENCE PLANTATIONS (US) | 1998-01-22 | — | — | WO | disclosed |
| US-5703084-A | Adenosine deaminase inhibitors | THE BOARD OF GOVERNORS FOR HIGHER EDUCATION, STATE OF RHODE ISLAND AND PROVIDENCE PLANTATIONS (US) | 1997-12-30 | — | — | US | disclosed |