Propentofylline

Propentofylline

SCHEMBL74602

CCCn1cnc2c1c(=O)n(CCCCC(C)=O)c(=O)n2C

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PDE4A P27815 10/20 1.00
LMNA P02545 2/20 1.00
CYP1A2 P05177 2/20 1.00
NFKB1 P19838 2/20 1.00
ACHE P22303 2/20 1.00
PMP22 Q01453 2/20 1.00
ESR1 P03372 1/20 1.00
MAPT P10636 1/20 1.00
BLM P54132 1/20 1.00
PDE4B Q07343 9/20 0.74
PDE4C Q08493 9/20 0.74
PDE4D Q08499 9/20 0.74
ADORA2B P29275 3/20 0.74
RXFP1 Q9HBX9 2/20 0.74
TNF P01375 2/20 0.74
USP2 O75604 1/20 0.74
TSHR P16473 1/20 0.74
SMN1; SMN2 Q16637 1/20 0.74
MAPK1 P28482 1/20 0.72
ADORA2A P29274 3/20 0.60

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7800905 0.99 PDE4A (0.98) PDE4ALMNACYP1A2NFKB1ACHE
SCHEMBL7798793 0.96 PDE4A (0.93) PDE4ALMNACYP1A2NFKB1ACHE
SCHEMBL7800864 0.95 PDE4A (0.91) PDE4ALMNACYP1A2NFKB1ACHE
SCHEMBL10788889 0.94 PDE4A (0.89) PDE4ALMNACYP1A2NFKB1ACHE
SCHEMBL11347084 0.94 PDE4A (0.89) PDE4ALMNACYP1A2NFKB1ACHE
SCHEMBL11345748 0.94 PDE4A (0.89) PDE4ALMNACYP1A2NFKB1ACHE
SCHEMBL11337820 0.94 PDE4A (0.89) PDE4ALMNACYP1A2NFKB1ACHE
SCHEMBL7802032 0.94 PDE4A (0.88) PDE4ALMNACYP1A2NFKB1ACHE
Propentofylline SCHEMBL28086100 0.93 PDE4A (0.86) PDE4ALMNACYP1A2NFKB1ACHE
Propentofylline SCHEMBL9027889 0.93 PDE4A (0.86) PDE4ALMNACYP1A2NFKB1ACHE

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 4800 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-122017251-A Marker group for sarcopenia screening and diagnosis and application thereof 四川大学华西医院 2026-05-12 CN claimed
US-12605345-B2 Transdermal drug delivery system BioPhysics Pharma, Inc. (US) 2026-04-21 US claimed
EP-3258950-B1 ALZHEIMER ABETA PEPTIDE BINDING POLYPEPTIDE AMYLONIX AB (SE) 2025-10-29 EP claimed
US-20250268841-A1 Trans-Epithelial Membrane Drug Delivery System Masiz, John J. (US) 2025-08-28 US claimed
US-12280057-B2 Vasoactive topical compound to affect tissue blood flow, reduce tissue necrosis and promote healing SOUTH DAKOTA BOARD OF REGENTS (US) 2025-04-22 US claimed
US-20250120907-A1 Transmucosal Drug Delivery System Masiz, John J. (US) 2025-04-17 US claimed
US-12246098-B2 Trans-epithelial membrane drug delivery system BioPhysics Pharma, Inc. (US) 2025-03-11 US claimed
WO-2025046257-A1 A SUBSTANTIALLY PURE PROPENTOFYLLINE AND PREPARATION THEREOF HIKAL LIMITED (IN) 2025-03-06 WO claimed
US-20250032503-A1 USE OF APREPITANT FOR TREATING ALZHEIMER'S DISEASE HOTH THERAPEUTICS, INC. 2025-01-30 US claimed
US-12133838-B2 Homotaurine-enriched compositions and methods of use for animal health FB MARIA SRL (IT) 2024-11-05 US claimed
EP-0069958-B2 Method for the preparation of gastro compatible pharmaceutical forms of xanthine derivatives. HOECHST AKTIENGESELLSCHAFT (DE) 1991-03-27 EP claimed
CN-1048659-A The preparation method of aqueogel and xerogel preparation HOECHST JAPAN (JP) 1991-01-23 CN claimed
EP-0386688-A1 Method for preparing hydrogel preparations and xerogel preparations HOECHST JAPAN LIMITED (JP) 1990-09-12 EP claimed
EP-0169466-B1 MIXTURE OF XANTHIN DERIVATIVES AND O-ACETYL-SALICYLIC ACID, OR THEIR PHARMACOLOGICALLY ACCEPTABLE SALTS, AND ITS USE HOECHST AKTIENGESELLSCHAFT (DE) 1990-04-04 EP claimed
EP-0305743-A2 Pharmaceutical mixture preparation, its manufacture and use HOECHST AKTIENGESELLSCHAFT (DE) 1989-03-08 EP claimed
US-4719212-A ALZHEIMER'S DISEASE HOECHST AKTIENGESELLSCHAFT (DE) 1988-01-12 US claimed
EP-0208962-A2 Combination preparations from thrombocyte aggregation inhibitors, and their use HOECHST AKTIENGESELLSCHAFT (DE) 1987-01-21 EP claimed
US-4636507-A Host defense mechanism enhancement HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) 1987-01-13 US claimed
EP-0069958-B1 Method for the preparation of gastro compatible pharmaceutical forms of xanthine derivatives. HOECHST AKTIENGESELLSCHAFT (DE) 1986-04-02 EP claimed
US-4542011-A PROTECTIVE COATINGS HOECHST AKTIENGESELLSCHAFT (DE) 1985-09-17 US claimed