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SCHEMBL7460488

SCHEMBL7460488

O=C(NCC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccn1)NC1CCN(C(=O)c2ccncc2)CC1

nearest known ligand 0.69

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
▸ CCR3 P51677 19/20 0.69
▸ CCR1 P32246 16/20 0.69

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7467249 0.94 CCR3 (0.66) CCR3CCR1
SCHEMBL7460774 0.91 CCR3 (0.61) CCR3CCR1
Hydrochloric Acid SCHEMBL7461439 0.89 CCR3 (0.72) CCR3CCR1
SCHEMBL7460473 0.87 CCR3 (0.74) CCR3CCR1
Hydrochloric Acid SCHEMBL7459245 0.86 CCR3 (0.67) CCR3CCR1
SCHEMBL7464865 0.83 CCR3 (0.84) CCR3CCR1
SCHEMBL7469228 0.83 CCR3 (0.87) CCR3CCR1
SCHEMBL7467246 0.82 CCR3 (0.69) CCR3CCR1
SCHEMBL7470943 0.82 CCR3 (0.82) CCR3CCR1
SCHEMBL7466210 0.81 CCR3 (0.86) CCR3CCR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1219294-A1 MELANIN CONCENTRATING HORMONE ANTAGONISTS Takeda Chemical Industries, Ltd. (JP) 2002-07-03 — — EP disclosed