Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | HTR7 | P34969 | 1/20 | 0.43 |
| ▸ | HTR6 | P50406 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | REV1 | Q9UBZ9 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7472167 | 1.00 | POLB (0.45) | POLBHTR1ADRD2HTR2AHTR7 | |
| SCHEMBL7468722 | 1.00 | POLB (0.45) | POLBHTR1ADRD2HTR2AHTR7 | |
| SCHEMBL7897454 | 0.85 | POLB (0.45) | POLBHTR1ADRD2HTR2AALDH1A1 | |
| SCHEMBL7902239 | 0.85 | POLB (0.45) | POLBHTR1ADRD2HTR2AALDH1A1 | |
| SCHEMBL7897452 | 0.85 | POLB (0.45) | POLBHTR1ADRD2HTR2AALDH1A1 | |
| SCHEMBL8797545 | 0.78 | KCNH2 (0.60) | HTR1ADRD2HTR2AHTR7HTR6 | |
| SCHEMBL7472153 | 0.77 | KMT2A (0.42) | POLBHTR7ALDH1A1SMN1; SMN2HTT | |
| SCHEMBL7464675 | 0.77 | KMT2A (0.42) | POLBHTR7ALDH1A1SMN1; SMN2HTT | |
| SCHEMBL7464067 | 0.77 | KMT2A (0.42) | POLBHTR7ALDH1A1SMN1; SMN2HTT | |
| SCHEMBL7464308 | 0.71 | POLB (0.53) | POLBHTR1AHTR2AHTR7HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1023273-B1 | CYCLOHEXANE DERIVATIVES DIFUNCTIONALISED IN 1,4 AS LIGANDS OF 5HT1A RECEPTORS | PF MEDICAMENT (FR) | 2002-06-05 | — | — | EP | claimed |
| US-6191130-B1 | HYPOTENSIVE AGENTS; THERAPY FOR SEXUAL DISORDERS; CENTRAL NERVOUS SYSTEM DISORDERS; PSYCHOLOGICAL DISORDERS | PIERRE FABRE MEDICAMENT (FR) | 2001-02-20 | — | — | US | claimed |
| US-6191130-B1 | HYPOTENSIVE AGENTS; THERAPY FOR SEXUAL DISORDERS; CENTRAL NERVOUS SYSTEM DISORDERS; PSYCHOLOGICAL DISORDERS | PIERRE FABRE MEDICAMENT (FR) | 2001-02-20 | — | — | US | disclosed |