Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 3/20 | 0.47 |
| ▸ | PIM2 | Q9P1W9 | 3/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.47 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.47 |
| ▸ | GSK3B | P49841 | 3/20 | 0.44 |
| ▸ | IGF1R | P08069 | 3/20 | 0.42 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.42 |
| ▸ | CDC7 | O00311 | 1/20 | 0.42 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.42 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
| ▸ | PHKG2 | P15735 | 1/20 | 0.42 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.42 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.42 |
| ▸ | CLK2 | P49760 | 1/20 | 0.42 |
| ▸ | GSK3A | P49840 | 1/20 | 0.42 |
| ▸ | NEK4 | P51957 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7464177 | 1.00 | PIM1 (0.47) | PIM1PIM2PDE4BPIM3GSK3B | |
| SCHEMBL14492729 | 0.86 | PTPN1 (0.42) | PIM1PIM2PDE4BPIM3GSK3B | |
| SCHEMBL5488084 | 0.86 | PTPN1 (0.42) | PIM1PIM2PDE4BPIM3GSK3B | |
| SCHEMBL5488085 | 0.86 | PTPN1 (0.42) | PIM1PIM2PDE4BPIM3GSK3B | |
| SCHEMBL5488144 | 0.86 | PTPN1 (0.48) | PIM1PIM2PDE4BPIM3GSK3B | |
| SCHEMBL14492585 | 0.86 | PTPN1 (0.48) | PIM1PIM2PDE4BPIM3GSK3B | |
| SCHEMBL5488140 | 0.86 | PTPN1 (0.48) | PIM1PIM2PDE4BPIM3GSK3B | |
| SCHEMBL7469497 | 0.83 | IGF1R (0.52) | PIM1PIM2PDE4BPIM3GSK3B | |
| SCHEMBL7469493 | 0.83 | IGF1R (0.52) | PIM1PIM2PDE4BPIM3GSK3B | |
| SCHEMBL7467691 | 0.83 | GSK3B (0.46) | PIM1PIM2PDE4BPIM3GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1214305-A1 | BENZYLIDENE-THIAZOLIDINEDIONES AND ANALOGUES AND THEIR USE IN THE TREATMENT OF INFLAMMATION | Maxia Pharmaceuticals, Inc. (US) | 2002-06-19 | — | — | EP | disclosed |
| WO-2001016123-A1 | BENZYLIDENE-THIAZOLIDINEDIONES AND ANALOGUES AND THEIR USE IN THE TREATMENT OF INFLAMMATION | MAXIA PHARMACEUTICALS, INC. (US) | 2001-03-08 | — | — | WO | disclosed |