Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 1/20 | 0.59 |
| ▸ | PPARA | Q07869 | 18/20 | 0.47 |
| ▸ | PPARD | Q03181 | 17/20 | 0.47 |
| ▸ | PPARG | P37231 | 16/20 | 0.47 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.47 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7461701 | 0.91 | GRM2 (0.58) | GRM2PPARAPPARDPPARGNR1H2 | |
| SCHEMBL7467346 | 0.91 | PPARA (0.50) | GRM2PPARAPPARDPPARGNR1H2 | |
| SCHEMBL7657026 | 0.87 | PPARA (0.51) | PPARAPPARDPPARGNR1H2NR1H3 | |
| SCHEMBL7460246 | 0.87 | PPARG (0.63) | PPARAPPARDPPARGNR1H2NR1H3 | |
| SCHEMBL7460491 | 0.86 | GRM2 (0.43) | GRM2PPARAPPARDPPARGNR1H2 | |
| SCHEMBL7665167 | 0.84 | PPARA (0.47) | GRM2PPARAPPARDPPARGNR1H2 | |
| SCHEMBL7466079 | 0.84 | PPARA (0.65) | PPARAPPARDPPARG | |
| SCHEMBL7462843 | 0.83 | PPARA (0.49) | GRM2PPARAPPARDPPARGNR1H2 | |
| SCHEMBL5208872 | 0.81 | GRM2 (0.59) | GRM2PPARAPPARDPPARGNR1H2 | |
| SCHEMBL7663384 | 0.79 | PPARA (0.50) | PPARAPPARDPPARGNR1H2NR1H3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6399640-B1 | ANTIDIABETIC AGENTS; ANTICHOLESTEROL AGENTS | MERCK & CO., INC. | 2002-06-04 | — | — | US | claimed |
| EP-1194146-A4 | ARYLTHIAZOLIDINEDIONE AND ARYLOXAZOLIDINEDIONE DERIVATIVES | MERCK & CO INC (US) | 2002-07-31 | — | — | EP | disclosed |
| US-6399640-B1 | ANTIDIABETIC AGENTS; ANTICHOLESTEROL AGENTS | MERCK & CO., INC. | 2002-06-04 | — | — | US | disclosed |
| EP-1194146-A1 | ARYLTHIAZOLIDINEDIONE AND ARYLOXAZOLIDINEDIONE DERIVATIVES | Merck & Co., Inc. (US) | 2002-04-10 | — | — | EP | disclosed |
| WO-2000078312-A1 | ARYLTHIAZOLIDINEDIONE AND ARYLOXAZOLIDINEDIONE DERIVATIVES | MERCK & CO., INC. (US) | 2000-12-28 | — | — | WO | disclosed |