Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 4/20 | 0.41 |
| ▸ | RAB9A | P51151 | 4/20 | 0.41 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.41 |
| ▸ | KCNK9 | Q9NPC2 | 2/20 | 0.40 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | PPARD | Q03181 | 1/20 | 0.39 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.39 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5787515 | 1.00 | MEN1 (0.41) | MEN1KMT2ARXFP1TDP1NPC1 | |
| SCHEMBL5786304 | 0.87 | RET (0.45) | RXFP1SMN1; SMN2BRD4 | |
| SCHEMBL4504444 | 0.86 | P2RX1 (0.40) | MEN1KMT2ARXFP1NPC1RAB9A | |
| SCHEMBL3141980 | 0.86 | KCNK9 (0.40) | MEN1KMT2ARXFP1TDP1NPC1 | |
| SCHEMBL5785822 | 0.86 | CHEK1 (0.45) | RXFP1KCNK9POLBCTDSP1CHEK1 | |
| SCHEMBL4505422 | 0.86 | KDR (0.42) | MEN1KMT2ARXFP1NPC1RAB9A | |
| SCHEMBL3148065 | 0.84 | POLB (0.41) | MEN1KMT2ARXFP1KCNK9KCNK3 | |
| SCHEMBL4501471 | 0.84 | RXFP1 (0.41) | MEN1KMT2ARXFP1NR1H4POLB | |
| SCHEMBL2571373 | 0.83 | RXFP1 (0.46) | MEN1KMT2ARXFP1NPC1RAB9A | |
| SCHEMBL6327111 | 0.81 | NPC1 (0.53) | MEN1KMT2ARXFP1TDP1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1212318-A1 | SUBSTITUTED INDOLINONES AS TYROSINE KINASE INHIBITORS | Boehringer Ingelheim Pharma KG (DE) | 2002-06-12 | — | — | EP | disclosed |
| WO-2001016130-A1 | SUBSTITUTED INDOLINONES AS TYROSINE KINASE INHIBITORS | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2001-03-08 | — | — | WO | disclosed |