Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1B | P28222 | 8/20 | 0.76 |
| ▸ | HTR1D | P28221 | 5/20 | 0.76 |
| ▸ | HTR1A | P08908 | 3/20 | 0.71 |
| ▸ | HTR6 | P50406 | 8/20 | 0.69 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.58 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.58 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.58 |
| ▸ | DRD1 | P21728 | 1/20 | 0.58 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.58 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.58 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.58 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.58 |
| ▸ | GABRP | O00591 | 1/20 | 0.58 |
| ▸ | GABRD | O14764 | 1/20 | 0.58 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.58 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.58 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.58 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.58 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.58 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8879229 | 1.00 | HTR1B (0.76) | HTR1BHTR1DHTR1AHTR6CHRM2 | |
| SCHEMBL8880205 | 1.00 | HTR1B (0.76) | HTR1BHTR1DHTR1AHTR6CHRM2 | |
| SCHEMBL8791178 | 0.96 | HTR1B (0.70) | HTR1BHTR1DHTR1AHTR6CHRM2 | |
| SCHEMBL8208343 | 0.86 | HTR1B (1.00) | HTR1BHTR1DHTR1AHTR6CHRM2 | |
| SCHEMBL8208346 | 0.86 | HTR1B (1.00) | HTR1BHTR1DHTR1AHTR6CHRM2 | |
| SCHEMBL8508432 | 0.86 | HTR1B (1.00) | HTR1BHTR1DHTR1AHTR6CHRM2 | |
| SCHEMBL1122175 | 0.85 | HTR1B (0.76) | HTR1BHTR1DHTR1AHTR6CHRM2 | |
| SCHEMBL772429 | 0.85 | HTR1B (0.76) | HTR1BHTR1DHTR1AHTR6CHRM2 | |
| SCHEMBL1122165 | 0.85 | HTR1B (0.76) | HTR1BHTR1DHTR1AHTR6CHRM2 | |
| SCHEMBL8209086 | 0.85 | HTR1B (0.76) | HTR1BHTR1DHTR1AHTR6GABRP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0782568-B1 | AROMATIC ETHERS DERIVED FROM INDOLS SUCH AS 5HT1-LIKE LIGANDS | PF MEDICAMENT (FR) | 2002-04-24 | — | — | EP | disclosed |
| US-5852049-A | Aromatic ethers derived from indoles which are useful as medicaments | PIERRE FABRE MEDICAMENT (FR) | 1998-12-22 | — | — | US | disclosed |
| WO-1997046525-A1 | 5-ALKOXY-TRYPTAMINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS 5-HT1D RECEPTOR AGONISTS | ALLELIX BIOPHARMACEUTICALS INC. (CA) | 1997-12-11 | — | — | WO | disclosed |
| US-5654431-A | EXHIBIT SELECTIVITY TOWARDS 5-HYDROXYTRYPTAMINE RECEPTORS OF BRAIN CELLS | ALLELIX BIOPHARMACEUTICALS INC. (CA) | 1997-08-05 | — | — | US | disclosed |
| EP-0782568-A1 | AROMATIC ETHERS DERIVED FROM INDOLS SUCH AS 5HT1-LIKE LIGANDS | PIERRE FABRE MEDICAMENT (FR) | 1997-07-09 | — | — | EP | disclosed |
| WO-1996009288-A1 | AROMATIC ETHERS DERIVED FROM INDOLS SUCH AS 5HT1-LIKE LIGANDS | PIERRE FABRE MEDICAMENT (FR) | 1996-03-28 | — | — | WO | disclosed |