SCHEMBL7465142

SCHEMBL7465142

CCOc1nsnc1Sc1nsnc1C1=CCCN(C)C1

nearest known ligand 0.77

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
CHRM1 P11229 15/20 0.77
CHRM4 P08173 5/20 0.64
CHRM2 P08172 2/20 0.63
CHRM5 P08912 2/20 0.63
CHRM3 P20309 2/20 0.63

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Oxalic Acid SCHEMBL7477183 0.94 CHRM1 (0.68) CHRM1
SCHEMBL7462827 0.91 CHRM1 (0.78) CHRM1CHRM4CHRM2CHRM5CHRM3
SCHEMBL6913185 0.87 CHRM1 (1.00) CHRM1CHRM4CHRM2CHRM5CHRM3
Oxalic Acid SCHEMBL7464573 0.85 CHRM1 (0.69) CHRM1CHRM4
SCHEMBL7469869 0.81 CHRM1 (0.72) CHRM1CHRM4CHRM2CHRM5CHRM3
SCHEMBL27456329 0.81 CHRM1 (0.71) CHRM1CHRM4CHRM2CHRM5CHRM3
Oxalic Acid SCHEMBL7609648 0.81 CHRM1 (0.86) CHRM1CHRM4CHRM2CHRM5CHRM3
Pyridine SCHEMBL27455798 0.80 CHRM1 (0.84) CHRM1CHRM4CHRM2CHRM5CHRM3
SCHEMBL6907655 0.80 CHRM1 (0.82) CHRM1CHRM4
Hydrochloric Acid SCHEMBL7900811 0.80 CHRM4 (0.97) CHRM1CHRM4CHRM2CHRM5CHRM3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0734259-B1 Use of piperidine compounds in the treatment of schizophrenia NOVO NORDISK AS (DK) 2002-06-12 EP claimed
EP-0687265-B1 HETEROCYCLIC COMPOUNDS AND THEIR PREPARATION AND USE NOVO NORDISK AS (DK) 2002-01-23 EP claimed
US-5773452-A ALZHEIMER'S DISEASE; COGNITION ACTIVATORS NOVO NORDISK ALS (DK) 1998-06-30 US claimed
CN-1133008-A Antipsychotic method NOVO NORDISK AS (DK) 1996-10-09 CN claimed
US-5545638-A USING A 3-(TETRAHYDROPYRID-3-YL-) SUBSTITUTED (OXA- OR THIA-)DIAZOLE COMPOUND NOVO NORDISK A/S (DK) 1996-08-13 US claimed
EP-0687265-B1 HETEROCYCLIC COMPOUNDS AND THEIR PREPARATION AND USE NOVO NORDISK AS (DK) 2002-01-23 EP disclosed
EP-0709094-B1 Tetrahydropyridine oxadiazole or thiadiazole compound for treating anxiety LILLY CO ELI (US) 2000-04-05 EP disclosed
US-5708014-A SUBSTITUTED TETRAHYDROPYRIDINYL-1,2,5-OXADIAZOLES OR THIADIAZOLES ELI LILLY AND COMPANY (US) 1998-01-13 US disclosed
EP-0709094-A2 Method for treating anxiety using a tetrahydropyridine oxadiazole or thiadiazole compound ELI LILLY AND COMPANY (US) 1996-05-01 EP disclosed