Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 1/20 | 0.43 |
| ▸ | CCR3 | P51677 | 2/20 | 0.40 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | MPL | P40238 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | HTR1B | P28222 | 4/20 | 0.39 |
| ▸ | HTR1A | P08908 | 3/20 | 0.38 |
| ▸ | HTR1D | P28221 | 2/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7467838 | 0.95 | CHEK2 (0.43) | GSK3BCCR3CHEK2CYP1A2CYP2D6 | |
| SCHEMBL7422886 | 0.95 | CHEK2 (0.46) | GSK3BCCR3CHEK2CYP1A2CYP2D6 | |
| SCHEMBL7417074 | 0.94 | CHEK2 (0.47) | GSK3BCCR3CHEK2CYP1A2CYP2D6 | |
| SCHEMBL7467711 | 0.89 | KDM4E (0.43) | CCR3CYP1A2CYP2D6HSD17B10MPL | |
| SCHEMBL7476488 | 0.86 | KMT2A (0.57) | GSK3BHSD17B10MEN1KMT2AATM | |
| SCHEMBL27528020 | 0.85 | CYP1A2 (0.43) | CCR3CHEK2CYP1A2CYP2D6HSD17B10 | |
| SCHEMBL7471184 | 0.84 | KDM4E (0.41) | CCR3CYP1A2CYP2D6HSD17B10MPL | |
| SCHEMBL7461131 | 0.84 | KDM4E (0.41) | CCR3HSD17B10MPLMEN1KMT2A | |
| SCHEMBL7425271 | 0.83 | SRD5A2 (0.43) | CCR3CHEK2HSD17B10MPLMEN1 | |
| SCHEMBL7424222 | 0.81 | HSD17B10 (0.43) | CCR3CHEK2CYP1A2CYP2D6HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0820441-B1 | INDOLE DERIVATIVES AS cGMP-PDE INHIBITORS | FUJISAWA PHARMACEUTICAL CO (JP) | 2002-06-26 | — | — | EP | disclosed |
| US-6358992-B1 | Method of inhibiting neoplastic cells with indole derivatives | CELL PATHWAYS, INC. | 2002-03-19 | — | — | US | disclosed |
| US-6069156-A | Indole derivatives as cGMP-PDE inhibitors | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2000-05-30 | — | — | US | disclosed |