Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 8/20 | 0.80 |
| ▸ | RAB9A | P51151 | 7/20 | 0.80 |
| ▸ | MAPT | P10636 | 5/20 | 0.80 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.80 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.80 |
| ▸ | HPGD | P15428 | 3/20 | 0.80 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.80 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.80 |
| ▸ | LMNA | P02545 | 1/20 | 0.80 |
| ▸ | TP53 | P04637 | 1/20 | 0.80 |
| ▸ | HTT | P42858 | 1/20 | 0.80 |
| ▸ | MEN1 | O00255 | 6/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.61 |
| ▸ | CASP3 | P42574 | 2/20 | 0.61 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.61 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.61 |
| ▸ | SENP6 | Q9GZR1 | 2/20 | 0.61 |
| ▸ | BLM | P54132 | 1/20 | 0.53 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.53 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13856498 | 0.89 | NPC1 (1.00) | NPC1RAB9AMAPTKDM4ESMN1; SMN2 | |
| SCHEMBL17457001 | 0.76 | NPC1 (1.00) | NPC1RAB9AMAPTKDM4ESMN1; SMN2 | |
| SCHEMBL13905634 | 0.73 | NPC1 (0.70) | NPC1RAB9AMAPTKDM4ESMN1; SMN2 | |
| SCHEMBL10372114 | 0.71 | NPC1 (0.56) | NPC1RAB9AMAPTKDM4ESMN1; SMN2 | |
| SCHEMBL25117970 | 0.71 | NPC1 (0.66) | NPC1RAB9AMAPTKDM4ESMN1; SMN2 | |
| SCHEMBL7463572 | 0.71 | KDM4E (0.43) | NPC1RAB9AMAPTKDM4ESMN1; SMN2 | |
| SCHEMBL4185031 | 0.70 | NPC1 (0.85) | NPC1RAB9AMAPTKDM4ESMN1; SMN2 | |
| SCHEMBL4219600 | 0.69 | MAPT (1.00) | NPC1RAB9AMAPTKDM4ESMN1; SMN2 | |
| SCHEMBL5132511 | 0.69 | KDM4E (0.45) | NPC1RAB9AMAPTKDM4ESMN1; SMN2 | |
| SCHEMBL4173777 | 0.68 | NPC1 (0.81) | NPC1RAB9AMAPTKDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0847271-B1 | PYRAZOLO-(1,5-a)-PYRIMIDINE DERIVATIVES, THEIR PREPARATION AND HAIR DYES CONTAINING THESE | OREAL (FR) | 2002-05-02 | — | — | EP | claimed |