SCHEMBL7468680

SCHEMBL7468680

CCCc1cnccc1CC

nearest known ligand 0.49

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
CYP2E1 P05181 6/20 0.49
CYP2C8 P10632 6/20 0.49
CYP2D6 P10635 6/20 0.49
CYP2A6 P11509 6/20 0.49
CYP2B6 P20813 6/20 0.49
CYP2C19 P33261 6/20 0.49
CYP2C9 P11712 5/20 0.49
CYP1A2 P05177 4/20 0.44
CYP3A4 P08684 3/20 0.44
AOC1 P19801 4/20 0.42
AOC3 Q16853 4/20 0.42
KDM4C Q9H3R0 1/20 0.40
PTGDR2 Q9Y5Y4 1/20 0.37
CCNC P24863 1/20 0.37
CDK8 P49336 1/20 0.37
TDP1 Q9NUW8 1/20 0.37
L3MBTL1 Q9Y468 1/20 0.37
LOXL2 Q9Y4K0 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8271491 0.91 CYP2E1 (0.49) CYP2E1CYP2C8CYP2D6CYP2A6CYP2B6
SCHEMBL10954433 0.91 CYP2E1 (0.51) CYP2E1CYP2C8CYP2D6CYP2A6CYP2B6
SCHEMBL877689 0.86 CYP2E1 (0.48) CYP2E1CYP2C8CYP2D6CYP2A6CYP2B6
SCHEMBL28328248 0.84 TDP1 (0.49) CYP2E1CYP2C8CYP2D6CYP2A6CYP2B6
SCHEMBL11564155 0.84 CYP2E1 (0.47) CYP2E1CYP2C8CYP2D6CYP2A6CYP2B6
SCHEMBL5109069 0.83 CYP2E1 (0.46) CYP2E1CYP2C8CYP2D6CYP2A6CYP2B6
SCHEMBL20643181 0.83 CYP2D6 (0.46) CYP2E1CYP2C8CYP2D6CYP2A6CYP2B6
SCHEMBL9201726 0.83 CYP2E1 (0.46) CYP2E1CYP2C8CYP2D6CYP2A6CYP2B6
SCHEMBL23488918 0.80 CYP2E1 (0.39) CYP2E1CYP2C8CYP2D6CYP2A6CYP2B6
SCHEMBL28040444 0.80 CYP2E1 (0.41) CYP2E1CYP2C8CYP2D6CYP2A6CYP2B6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3712151-A1 SPIRO AROMATIC RING COMPOUND AND APPLICATION THEREOF Etern Biopharma (Shanghai) Co., Ltd. (CN) 2020-09-23 EP disclosed
EP-0650476-B1 PERIPHERAL VASODILATING AGENT CONTAINING N-ACYLATED 4-AMINO PIPERIDINE DERIVATIVES AS ACTIVE INGREDIENTS OTSUKA PHARMA CO LTD (JP) 2002-06-26 EP disclosed
US-6136826-A AMINOPIPERIDINE COMPOUNDS SUBSTITUTED WITH ALKANOYL OTSUKA PHARMACEUTICAL CO., LTD. (JP) 2000-10-24 US disclosed
US-5760058-A Peripheral vasodilating agent containing piperidine derivative as active ingredient OTSUKA PHARMACEUTICAL CO., LTD. (JP) 1998-06-02 US disclosed
US-5656642-A Peripheral vasodilating agent containing piperidine derivative as active ingredient OTSUKA PHARMACEUTICAL CO., LTD. (JP) 1997-08-12 US disclosed
WO-1994022826-A1 PERIPHERAL VASODILATING AGENT CONTAINING N-ACYLATED 4-AMINO PIPERIDINE DERIVATIVES AS ACTIVE INGREDIENTS OTSUKA PHARMACEUTICAL CO., LTD. (JP) 1994-10-13 WO disclosed