Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 10/20 | 0.56 |
| ▸ | CCR1 | P32246 | 2/20 | 0.38 |
| ▸ | CCR2 | P41597 | 2/20 | 0.38 |
| ▸ | CCR4 | P51679 | 2/20 | 0.38 |
| ▸ | CTSK | P43235 | 1/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.37 |
| ▸ | FLT1 | P17948 | 1/20 | 0.37 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.37 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.37 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.37 |
| ▸ | FLT4 | P35916 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | DPP4 | P27487 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
| ▸ | TYK2 | P29597 | 1/20 | 0.33 |
| ▸ | JAK3 | P52333 | 1/20 | 0.33 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.32 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.32 |
| ▸ | EGLN2 | Q96KS0 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9156641 | 0.72 | CYP19A1 (1.00) | CYP19A1 | |
| SCHEMBL12468796 | 0.72 | CYP19A1 (0.50) | CYP19A1CCR1CCR2CCR4DPP4 | |
| SCHEMBL27453502 | 0.71 | CYP19A1 (0.68) | CYP19A1CCR1CCR2CCR4 | |
| SCHEMBL27864568 | 0.65 | CYP11B1 (0.50) | CYP19A1CCR1CCR2CCR4CTSK | |
| SCHEMBL5468353 | 0.65 | DPP4 (0.50) | CYP19A1CCR1CCR2CCR4DPP4 | |
| SCHEMBL536576 | 0.64 | EPAS1 (0.37) | CYP19A1EGLN2 | |
| SCHEMBL12184920 | 0.64 | CYP2A6 (0.41) | CYP19A1EGLN2 | |
| SCHEMBL17514977 | 0.64 | TTR (0.32) | CYP19A1EGLN2 | |
| SCHEMBL20967889 | 0.64 | CYP11B1 (0.33) | CYP19A1EGLN2 | |
| SCHEMBL17864267 | 0.64 | TTR (0.37) | CYP19A1EGLN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0918758-B1 | PROCESS FOR PREPARING 1-SUBSTITUTED 4-CYANO-1,2,3-TRIAZOLES | NOVARTIS AG (CH) | 2002-05-02 | — | — | EP | disclosed |
| US-6277999-B1 | AS CHEMICAL INTERMEDIATE FOR PREPARATION OF DRUGS | NOVARTIS AG (CH) | 2001-08-21 | — | — | US | disclosed |
| US-6156907-A | Process for preparing 1-substituted 4-cyano-1,2,3-triazoles | NOVARTIS AG (CH) | 2000-12-05 | — | — | US | disclosed |
| EP-0918758-A1 | PROCESS FOR PREPARING 1-SUBSTITUTED 4-CYANO-1,2,3-TRIAZOLES | Novartis AG (CH) | 1999-06-02 | — | — | EP | disclosed |
| WO-1998002423-A1 | PROCESS FOR PREPARING 1-SUBSTITUTED 4-CYANO-1,2,3-TRIAZOLES | NOVARTIS AG (CH) | 1998-01-22 | — | — | WO | disclosed |