SCHEMBL7470028

SCHEMBL7470028

CC(C)(C)OC(=O)CCC(=O)N(N)CC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1

nearest known ligand 0.61

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
CCR3 P51677 12/20 0.61
CCR1 P32246 12/20 0.61
DRD2 P14416 3/20 0.52
OPRM1 P35372 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7455825 0.78 CCR3 (0.59) CCR3CCR1OPRM1
SCHEMBL7470032 0.78 CCR3 (0.67) CCR3CCR1
SCHEMBL8891231 0.77 CCR1 (1.00) CCR3CCR1OPRM1
SCHEMBL7470015 0.77 CCR3 (0.70) CCR3CCR1DRD2
SCHEMBL7463924 0.76 CCR3 (0.71) CCR3CCR1
Hydrochloric Acid SCHEMBL7469900 0.76 CCR3 (0.70) CCR3CCR1
SCHEMBL7463936 0.75 CCR1 (0.60) CCR3CCR1
SCHEMBL7470022 0.75 CCR3 (0.67) CCR3CCR1
SCHEMBL8921760 0.75 CCR3 (0.61) CCR3CCR1OPRM1
Hydrochloric Acid SCHEMBL7469905 0.75 CCR1 (0.59) CCR3CCR1OPRM1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1219294-A1 MELANIN CONCENTRATING HORMONE ANTAGONISTS Takeda Chemical Industries, Ltd. (JP) 2002-07-03 EP disclosed