Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 13/20 | 0.48 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7465855 | 0.85 | SMN1; SMN2 (0.41) | PTGDR2SCN9ATP53MAPT | |
| SCHEMBL7469133 | 0.85 | HDAC1 (0.49) | PTGDR2SCN9AHDAC1HDAC6TP53 | |
| SCHEMBL7465042 | 0.84 | PTGDR2 (0.51) | PTGDR2SCN9ATP53MAPTC5AR1 | |
| SCHEMBL7460259 | 0.83 | SCN9A (0.46) | PTGDR2SCN9AHDAC1HDAC6TP53 | |
| SCHEMBL7472348 | 0.81 | TP53 (0.44) | PTGDR2SCN9AHDAC1HDAC6TP53 | |
| SCHEMBL8742795 | 0.77 | PTGDR2 (0.48) | PTGDR2SCN9AHDAC1HDAC6TP53 | |
| SCHEMBL7476150 | 0.74 | PTGDR2 (0.45) | PTGDR2SCN9AHDAC1HDAC6TP53 | |
| SCHEMBL7465337 | 0.73 | MAPT (0.39) | SCN9AHDAC1HDAC6TP53MAPT | |
| SCHEMBL8588887 | 0.73 | MEN1 (0.42) | PTGDR2MAPT | |
| Water SCHEMBL8593336 | 0.73 | MAPT (0.39) | SCN9AHDAC1HDAC6TP53MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0687251-B1 | 1,3-DIHYDROINDOL-2-ONE DERIVATIVES SUBSTITUTED IN POSITION 3 BY A NITROGEN GROUP AS VASOPRESSIN AND/OR OCYTOCINE AGONISTS AND/OR ANTAGONISTS | SANOFI SYNTHELABO (FR) | 2002-02-27 | — | — | EP | disclosed |
| US-5594023-A | 1,3-dihydroindol-2-one derivatives substituted in the 3-position by a nitrogen-containing group, their preparation and the pharmaceutical compositions in which they are present | SANOFI (FR) | 1997-01-14 | — | — | US | disclosed |