Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.40 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.40 |
| ▸ | HCRTR2 | O43614 | 4/20 | 0.39 |
| ▸ | HCRTR1 | O43613 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | UBE2M | P61081 | 3/20 | 0.34 |
| ▸ | DCUN1D1 | Q96GG9 | 3/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | KDM2B | Q8NHM5 | 3/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | IKBKB | O14920 | 1/20 | 0.34 |
| ▸ | CHUK | O15111 | 1/20 | 0.34 |
| ▸ | IKBKG | Q9Y6K9 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7471211 | 1.00 | KDM4E (0.40) | KDM4EPOLBNPBWR1MCHR1HCRTR2 | |
| SCHEMBL7465681 | 0.89 | KDM4E (0.40) | KDM4EPOLBNPBWR1MCHR1HCRTR2 | |
| SCHEMBL7467159 | 0.87 | HTR2B (0.37) | POLBNPC1MAPTCHRM2KDM2B | |
| SCHEMBL7471215 | 0.82 | NPC1 (0.48) | KDM4EHCRTR2HCRTR1NPC1KLF5 | |
| SCHEMBL7470152 | 0.81 | KDM4E (0.35) | KDM4EPOLBNPBWR1MCHR1NPC1 | |
| Hydrochloric Acid SCHEMBL7475856 | 0.78 | MAPT (0.37) | KDM4EPOLBNPC1TP53MAPT | |
| SCHEMBL7469785 | 0.78 | KDM4E (0.40) | KDM4EPOLBNPBWR1MCHR1TP53 | |
| SCHEMBL7469782 | 0.78 | KDM4E (0.40) | KDM4EPOLBNPBWR1MCHR1TP53 | |
| SCHEMBL7473250 | 0.78 | KDM4E (0.41) | KDM4EPOLBNPBWR1MCHR1HCRTR2 | |
| SCHEMBL7468395 | 0.76 | KDM4E (0.39) | KDM4EPOLBNPBWR1MCHR1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0858452-B1 | THIAZOLE DERIVATIVE AS PROTEIN KINASE C INHIBITORS | OTSUKA PHARMA CO LTD (JP) | 2002-03-13 | — | — | EP | claimed |
| US-6140330-A | USEFUL AS PROTEIN KINASE INHIBITOR; FOR TREATMENT OF AUTOIMMUNE DISEASES SUCH AS RHEUMATOID ARTHRITIS, SYSTEMIC LUPUS ERYTHEMATOSUS, MULTIPLE SCLEROSIS, PSORIASIS, ETC., VARIOUS ALLERGIC DISEASES SUCH AS CROHN'S DISEASE, ASTHMA | OTSUKA PHARMACEUTICAL COMPANY, LIMITED (JP) | 2000-10-31 | — | — | US | claimed |
| EP-0858452-A1 | THIAZOLE DERIVATIVE AS PROTEIN KINASE C INHIBITORS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1998-08-19 | — | — | EP | claimed |
| WO-1998004536-A1 | THIAZOLE DERIVATIVE AS PROTEIN KINASE C INHIBITORS | OTSUKA PHARMACEUTICAL COMPANY, LIMITED (JP) | 1998-02-05 | — | — | WO | claimed |