Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AVPR1B | P47901 | 17/20 | 0.42 |
| ▸ | AVPR1A | P37288 | 7/20 | 0.42 |
| ▸ | OXTR | P30559 | 6/20 | 0.42 |
| ▸ | AVPR2 | P30518 | 3/20 | 0.42 |
| ▸ | GPR65 | Q8IYL9 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7472067 | 0.93 | AVPR1B (0.44) | AVPR1BAVPR1AOXTRAVPR2GPR65 | |
| SCHEMBL7467205 | 0.90 | AVPR1B (0.46) | AVPR1BAVPR1AOXTRAVPR2GPR65 | |
| SCHEMBL7466089 | 0.88 | AVPR1B (0.40) | AVPR1BAVPR1AOXTRAVPR2GPR65 | |
| SCHEMBL7467483 | 0.86 | POLB (0.42) | AVPR1BAVPR1AOXTRAVPR2GPR65 | |
| SCHEMBL7471178 | 0.84 | AVPR1B (0.54) | AVPR1BAVPR1AOXTRAVPR2GPR65 | |
| SCHEMBL7471418 | 0.84 | AVPR1B (0.43) | AVPR1BAVPR1AOXTRAVPR2GPR65 | |
| SCHEMBL7470397 | 0.83 | SMN1; SMN2 (0.41) | AVPR1BAVPR1AOXTRAVPR2GPR65 | |
| SCHEMBL7464945 | 0.83 | AVPR1B (0.45) | AVPR1BAVPR1AOXTRAVPR2GPR65 | |
| SCHEMBL7468544 | 0.82 | AVPR1B (0.54) | AVPR1BAVPR1AOXTRAVPR2GPR65 | |
| SCHEMBL7466480 | 0.82 | AVPR1B (0.52) | AVPR1BAVPR1AOXTRAVPR2GPR65 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0687251-B1 | 1,3-DIHYDROINDOL-2-ONE DERIVATIVES SUBSTITUTED IN POSITION 3 BY A NITROGEN GROUP AS VASOPRESSIN AND/OR OCYTOCINE AGONISTS AND/OR ANTAGONISTS | SANOFI SYNTHELABO (FR) | 2002-02-27 | — | — | EP | disclosed |
| US-5773612-A | VASOPRESSIN OR OXYTOCIN RECEPTORS | SANOFI (FR) | 1998-06-30 | — | — | US | disclosed |
| US-5594023-A | 1,3-dihydroindol-2-one derivatives substituted in the 3-position by a nitrogen-containing group, their preparation and the pharmaceutical compositions in which they are present | SANOFI (FR) | 1997-01-14 | — | — | US | disclosed |
| WO-1995018105-A1 | 1,3-DIHYDROINDOL-2-ONE DERIVATIVES SUBSTITUTED IN POSITION 3 BY A NITROGEN GROUP AS VASOPRESSIN AND/OR OCYTOCINE AGONISTS AND/OR ANTAGONISTS | SANOFI (FR) | 1995-07-06 | — | — | WO | disclosed |