⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22658159 | 0.84 | — | — | |
| SCHEMBL10101158 | 0.78 | CRBN (0.53) | — | |
| SCHEMBL4240098 | 0.76 | — | — | |
| SCHEMBL18396750 | 0.72 | — | — | |
| Thiazolidine SCHEMBL8794184 | 0.72 | CRBN (0.52) | — | |
| SCHEMBL57039 | 0.71 | — | — | |
| SCHEMBL27475685 | 0.69 | — | — | |
| SCHEMBL27471834 | 0.69 | — | — | |
| SCHEMBL1593092 | 0.69 | — | — | |
| 2-Pyrrolidone SCHEMBL27529551 | 0.67 | OR51E2 (0.62) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1706147-A2 | COMBINATION THERAPY WITH 5-HT sb 1A /sb AND 5-HT sb 1B /sb RECEPTOR ANTAGONISTS | Recordati Ireland Limited (IE) | 2006-10-04 | — | — | EP | claimed |
| WO-2005070460-A2 | COMBINATION THERAPY WITH 5-HT1A AND 5-HT1B RECEPTOR ANTAGONISTS | RECORDATI IRELAND LIMITED (IE) | 2005-08-04 | — | — | WO | claimed |
| WO-2023190015-A1 | 1-ARYL TETRAHYDROPYRIDAZINE-3,5-DIONE DERIVATIVE OR SALT THEREOF, PESTICIDE CONTAINING SAID COMPOUND, AND METHOD FOR USING SAME | 日本農薬株式会社 | 2023-10-05 | — | — | WO | disclosed |
| WO-2014169845-A2 | 4,5-DIHYDRO-PYRAZOLO [3, 4-C] PYRID-2-ONES, PREPARATION METHOD AND APPLICATION THEREOF | 四川海思科制药有限公司 (CN) | 2014-10-23 | — | — | WO | disclosed |
| US-20130338367-A1 | PYRAZOLE DERIVATIVES AND PESTICIDES | NISSAN CHEMICAL INDUSTRIES, LTD. (JP) | 2013-12-19 | — | — | US | disclosed |
| EP-2674423-A1 | PYRAZOLE DERIVATIVE AND PEST CONTROL AGENT | Nissan Chemical Industries, Ltd. (JP) | 2013-12-18 | — | — | EP | disclosed |
| US-20120088759-A1 | THIAZOLIDIN-4-ONE AND [1,3]-THIAZINAN-4-ONE COMPOUNDS AS OREXIN RECEPTOR ANTAGONISTS | ACTELION PHARMACEUTICALS LTD. (CH) | 2012-04-12 | — | — | US | disclosed |
| US-20120088759-A1 | THIAZOLIDIN-4-ONE AND [1,3]-THIAZINAN-4-ONE COMPOUNDS AS OREXIN RECEPTOR ANTAGONISTS | ACTELION PHARMACEUTICALS LTD. (CH) | 2012-04-12 | — | — | US | disclosed |
| CN-102413828-A | Thiazolidin-4-one and [1,3] -thiazinan-4-one compounds as orexin receptor antagonists | ACTELION PHARMACEUTICALS LTD | 2012-04-11 | — | — | CN | disclosed |
| CN-102413828-A | Thiazolidin-4-one and [1,3] -thiazinan-4-one compounds as orexin receptor antagonists | ACTELION PHARMACEUTICALS LTD | 2012-04-11 | — | — | CN | disclosed |
| EP-2429523-A1 | THIAZOLIDIN-4-ONE AND [1,3]-THIAZINAN-4-ONE COMPOUNDS AS OREXIN RECEPTOR ANTAGONISTS | Actelion Pharmaceuticals Ltd. (CH) | 2012-03-21 | — | — | EP | disclosed |
| US-6627627-B2 | Useful as psychotherapeutic agents | PFIZER INC. | 2003-09-30 | — | — | US | disclosed |
| CN-1031570-C | Pyrazolopyridine compound and processes for preparation thereof | FUJISAWA PHARMACEUTICAL CO (JP) | 1996-04-17 | — | — | CN | disclosed |
| US-5155114-A | Treating or preventing renal toxicity, nephrosis, nephritis | FUJISAWA PHARMACEUTICAL COMPANY, LTD. (JP) | 1992-10-13 | — | — | US | disclosed |
| US-5098899-A | Method for therapeutically treating psoriatic arthritis using vitamin D analogues and metabolites | TRUSTEES OF BOSTON UNIVERSITY (US) | 1992-03-24 | — | — | US | disclosed |
| US-4985444-A | Pyrazolopyridine compound and processes for preparation thereof | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1991-01-15 | — | — | US | disclosed |
| EP-0379979-A1 | Pyrazolopyridine compounds and processes for preparation thereof | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1990-08-01 | — | — | EP | disclosed |
| EP-0236931-A2 | Aromatic omega-alkylimino-tetrahydro-6H-1,3-Thiazin-6-one derivatives | MERRELL DOW PHARMACEUTICALS INC. (US) | 1987-09-16 | — | — | EP | disclosed |
| US-4301151-A | OLIGOPEPTIDES CONTAINING A 1,3-THIAZIN-4-ONE RING OR A N-HETERO-4-ONE RINGS | MERCK & CO., INC. (US) | 1981-11-17 | — | — | US | disclosed |
| US-4254107-A | Long-lasting agonists of enkephalin | MERCK & CO., INC. (US) | 1981-03-03 | — | — | US | disclosed |