Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AVPR1B | P47901 | 17/20 | 0.42 |
| ▸ | OXTR | P30559 | 7/20 | 0.42 |
| ▸ | AVPR1A | P37288 | 7/20 | 0.42 |
| ▸ | AVPR2 | P30518 | 3/20 | 0.42 |
| ▸ | GPR65 | Q8IYL9 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7469533 | 0.96 | AVPR1B (0.43) | AVPR1BOXTRAVPR1AAVPR2GPR65 | |
| SCHEMBL7462148 | 0.94 | AVPR1B (0.43) | AVPR1BOXTRAVPR1AAVPR2GPR65 | |
| SCHEMBL7476157 | 0.92 | AVPR1A (0.38) | AVPR1BOXTRAVPR1AAVPR2GPR65 | |
| SCHEMBL7471418 | 0.89 | AVPR1B (0.43) | AVPR1BOXTRAVPR1AAVPR2GPR65 | |
| SCHEMBL7468172 | 0.87 | AVPR1B (0.43) | AVPR1BOXTRAVPR1AAVPR2GPR65 | |
| SCHEMBL8742777 | 0.87 | POLB (0.45) | AVPR1BOXTRAVPR1AAVPR2GPR65 | |
| SCHEMBL7464945 | 0.87 | AVPR1B (0.45) | AVPR1BOXTRAVPR1AAVPR2GPR65 | |
| SCHEMBL7467475 | 0.87 | AVPR1B (0.52) | AVPR1BOXTRAVPR1AAVPR2GPR65 | |
| SCHEMBL7471178 | 0.85 | AVPR1B (0.54) | AVPR1BOXTRAVPR1AAVPR2GPR65 | |
| SCHEMBL7469886 | 0.84 | POLB (0.46) | AVPR1BOXTRAVPR1AAVPR2GPR65 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0687251-B1 | 1,3-DIHYDROINDOL-2-ONE DERIVATIVES SUBSTITUTED IN POSITION 3 BY A NITROGEN GROUP AS VASOPRESSIN AND/OR OCYTOCINE AGONISTS AND/OR ANTAGONISTS | SANOFI SYNTHELABO (FR) | 2002-02-27 | — | — | EP | disclosed |
| US-5773612-A | VASOPRESSIN OR OXYTOCIN RECEPTORS | SANOFI (FR) | 1998-06-30 | — | — | US | disclosed |
| US-5594023-A | 1,3-dihydroindol-2-one derivatives substituted in the 3-position by a nitrogen-containing group, their preparation and the pharmaceutical compositions in which they are present | SANOFI (FR) | 1997-01-14 | — | — | US | disclosed |
| WO-1995018105-A1 | 1,3-DIHYDROINDOL-2-ONE DERIVATIVES SUBSTITUTED IN POSITION 3 BY A NITROGEN GROUP AS VASOPRESSIN AND/OR OCYTOCINE AGONISTS AND/OR ANTAGONISTS | SANOFI (FR) | 1995-07-06 | — | — | WO | disclosed |