Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AVPR1B | P47901 | 17/20 | 0.46 |
| ▸ | AVPR1A | P37288 | 6/20 | 0.46 |
| ▸ | OXTR | P30559 | 6/20 | 0.46 |
| ▸ | AVPR2 | P30518 | 3/20 | 0.46 |
| ▸ | GPR65 | Q8IYL9 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.38 |
| ▸ | TTR | P02766 | 1/20 | 0.38 |
| ▸ | FABP4 | P15090 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7475235 | 0.92 | AVPR1B (0.45) | AVPR1BAVPR1AOXTRAVPR2GPR65 | |
| SCHEMBL7472589 | 0.91 | AVPR1B (0.44) | AVPR1BAVPR1AOXTRAVPR2GPR65 | |
| SCHEMBL8594323 | 0.89 | AVPR1B (0.42) | AVPR1BAVPR1AOXTRAVPR2GPR65 | |
| SCHEMBL7467205 | 0.89 | AVPR1B (0.46) | AVPR1BAVPR1AOXTRAVPR2GPR65 | |
| SCHEMBL7471384 | 0.86 | AVPR1B (0.44) | AVPR1BAVPR1AOXTRAVPR2GPR65 | |
| SCHEMBL7470715 | 0.85 | POLB (0.44) | AVPR1BAVPR1AOXTRAVPR2GPR65 | |
| SCHEMBL7473969 | 0.85 | AVPR1B (0.46) | AVPR1BAVPR1AOXTRAVPR2GPR65 | |
| SCHEMBL8591842 | 0.84 | AVPR1B (0.39) | AVPR1BAVPR1AOXTRAVPR2GPR65 | |
| SCHEMBL7471178 | 0.83 | AVPR1B (0.54) | AVPR1BAVPR1AOXTRAVPR2GPR65 | |
| SCHEMBL7468544 | 0.83 | AVPR1B (0.54) | AVPR1BAVPR1AOXTRAVPR2GPR65 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0687251-B1 | 1,3-DIHYDROINDOL-2-ONE DERIVATIVES SUBSTITUTED IN POSITION 3 BY A NITROGEN GROUP AS VASOPRESSIN AND/OR OCYTOCINE AGONISTS AND/OR ANTAGONISTS | SANOFI SYNTHELABO (FR) | 2002-02-27 | — | — | EP | disclosed |
| US-5594023-A | 1,3-dihydroindol-2-one derivatives substituted in the 3-position by a nitrogen-containing group, their preparation and the pharmaceutical compositions in which they are present | SANOFI (FR) | 1997-01-14 | — | — | US | disclosed |