Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 5/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | KLK7 | P49862 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6332666 | 1.00 | RET (0.45) | RETMAPTLMNASMN1; SMN2KLK7 | |
| SCHEMBL6332672 | 1.00 | RET (0.45) | RETMAPTLMNASMN1; SMN2KLK7 | |
| SCHEMBL6329199 | 0.89 | RET (0.47) | RETMAPTEPHX2GAA | |
| SCHEMBL7474775 | 0.89 | RET (0.47) | RETMAPTEPHX2GAA | |
| SCHEMBL6329207 | 0.89 | RET (0.47) | RETMAPTEPHX2GAA | |
| SCHEMBL6337231 | 0.88 | CHEK1 (0.45) | RETEPHX2CHEK1GAA | |
| SCHEMBL6337227 | 0.88 | CHEK1 (0.45) | RETEPHX2CHEK1GAA | |
| SCHEMBL6330792 | 0.88 | RET (0.44) | RETMEN1KMT2AEPHX2CHEK1 | |
| SCHEMBL6330783 | 0.88 | RET (0.44) | RETMEN1KMT2AEPHX2CHEK1 | |
| SCHEMBL6336093 | 0.86 | MAPT (0.54) | RETMAPTLMNASMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1212318-A1 | SUBSTITUTED INDOLINONES AS TYROSINE KINASE INHIBITORS | Boehringer Ingelheim Pharma KG (DE) | 2002-06-12 | — | — | EP | disclosed |
| WO-2001016130-A1 | SUBSTITUTED INDOLINONES AS TYROSINE KINASE INHIBITORS | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2001-03-08 | — | — | WO | disclosed |