Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARD | Q03181 | 18/20 | 0.73 |
| ▸ | PPARA | Q07869 | 18/20 | 0.73 |
| ▸ | PPARG | P37231 | 17/20 | 0.73 |
| ▸ | NR1H2 | P55055 | 6/20 | 0.73 |
| ▸ | NR1H3 | Q13133 | 6/20 | 0.73 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5204898 | 0.91 | PPARA (0.61) | PPARDPPARAPPARGNR1H2NR1H3 | |
| SCHEMBL7038876 | 0.89 | PPARD (0.60) | PPARDPPARAPPARGNR1H2NR1H3 | |
| SCHEMBL7042207 | 0.89 | PPARD (0.60) | PPARDPPARAPPARGNR1H2NR1H3 | |
| SCHEMBL7044588 | 0.88 | PPARG (0.73) | PPARDPPARAPPARGNR1H2NR1H3 | |
| SCHEMBL6368217 | 0.86 | GRM2 (0.59) | PPARDPPARAPPARGNR1H2NR1H3 | |
| SCHEMBL5209083 | 0.83 | PPARA (0.60) | PPARDPPARAPPARGNR1H2NR1H3 | |
| SCHEMBL7039181 | 0.83 | PPARD (0.62) | PPARDPPARAPPARGNR1H2NR1H3 | |
| SCHEMBL7042295 | 0.83 | PPARA (1.00) | PPARDPPARAPPARGNR1H2NR1H3 | |
| SCHEMBL7041508 | 0.82 | PPARG (0.75) | PPARDPPARAPPARGNR1H2NR1H3 | |
| SCHEMBL6925941 | 0.82 | PPARD (0.54) | PPARDPPARAPPARGNR1H2NR1H3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1040102-A4 | ARYLTHIAZOLIDINEDIONE DERIVATIVES | MERCK & CO INC (US) | 2002-11-27 | — | — | EP | disclosed |
| EP-1040102-A1 | ARYLTHIAZOLIDINEDIONE DERIVATIVES | Merck & Co., Inc. (US) | 2000-10-04 | — | — | EP | disclosed |
| WO-1999032465-A1 | ARYLTHIAZOLIDINEDIONE DERIVATIVES | MERCK & CO., INC. (US) | 1999-07-01 | — | — | WO | disclosed |