Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRN | P28799 | 5/20 | 0.62 |
| ▸ | SORT1 | Q99523 | 5/20 | 0.62 |
| ▸ | NPSR1 | Q6W5P4 | 6/20 | 0.51 |
| ▸ | GAA | P10253 | 5/20 | 0.49 |
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | CRHBP | P24387 | 1/20 | 0.44 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12050569 | 0.78 | GRN (0.64) | GRNSORT1NPSR1GAAMAPT | |
| SCHEMBL13990638 | 0.78 | GRN (0.64) | GRNSORT1NPSR1GAAMAPT | |
| SCHEMBL1010749 | 0.77 | GRN (0.62) | GRNSORT1NPSR1GAAMAPT | |
| SCHEMBL3069753 | 0.77 | GRN (1.00) | GRNSORT1NPSR1GAAMAPT | |
| SCHEMBL3720684 | 0.77 | GRN (0.62) | GRNSORT1NPSR1GAAMAPT | |
| SCHEMBL21919193 | 0.76 | GRN (0.61) | GRNSORT1NPSR1GAAMAPT | |
| SCHEMBL13219146 | 0.75 | GRN (0.82) | GRNSORT1NPSR1GAAMAPT | |
| SCHEMBL893061 | 0.75 | GRN (0.82) | GRNSORT1NPSR1GAAMAPT | |
| SCHEMBL20933027 | 0.75 | GRN (0.63) | GRNSORT1NPSR1GAAMAPT | |
| SCHEMBL1897360 | 0.74 | GRN (0.80) | GRNSORT1NPSR1GAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1054886-B1 | HETEROARYL AMIDINES, METHYLAMIDINES AND GUANIDINES AS PROTEASE INHIBITORS, IN PARTICULAR AS UROKINASE INHIBITORS | DIMENSIONAL PHARM INC (US) | 2002-09-04 | — | — | EP | disclosed |
| WO-1999048868-A9 | HETEROCYCLIC CLASSES OF COMPOUNDS FOR THE MODULATING TYROSINE PROTEIN KINASE | SUGEN INC (US) | 2000-04-20 | — | — | WO | disclosed |