Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 13/20 | 0.58 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.57 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.54 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.54 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7473700 | 1.00 | HDAC8 (0.58) | HDAC8PTPN1OPRM1OPRD1OPRK1 | |
| SCHEMBL7536598 | 0.89 | PTPN1 (0.71) | HDAC8PTPN1 | |
| SCHEMBL19329100 | 0.89 | PTPN1 (0.71) | HDAC8PTPN1 | |
| SCHEMBL3991209 | 0.85 | HDAC8 (0.51) | HDAC8PTPN1 | |
| SCHEMBL30254985 | 0.85 | PTPN1 (0.54) | HDAC8PTPN1OPRM1OPRD1OPRK1 | |
| SCHEMBL29773931 | 0.85 | PTPN1 (0.54) | HDAC8PTPN1OPRM1OPRD1OPRK1 | |
| SCHEMBL29502321 | 0.85 | PTPN1 (0.54) | HDAC8PTPN1OPRM1OPRD1OPRK1 | |
| SCHEMBL19460727 | 0.85 | PTPN1 (0.54) | HDAC8PTPN1 | |
| SCHEMBL864823 | 0.85 | PTPN1 (0.54) | HDAC8PTPN1OPRM1OPRD1OPRK1 | |
| SCHEMBL19460728 | 0.85 | PTPN1 (0.54) | HDAC8PTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1045844-A4 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 2002-08-21 | — | — | EP | disclosed |
| EP-1045844-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 2000-10-25 | — | — | EP | disclosed |
| US-5932590-A | PEPTIDOMIMETIC IMIDAZOLYL-CONTAINING 1,2,3,4-TETRAHYDRO-QUINOLINES OR AN ANALOGOUS 3-BENZAZEPINES; ANTICARCINOGENIC AND-PROLIFERATIVE AGENTS; POLYCYSTIC KIDNEY DISEASE; RESTENOSIS PREVENTION; HEPATITIS; RETINAL VASCULARZATION | MERCK & CO., INC. (US) | 1999-08-03 | — | — | US | disclosed |
| WO-1999028314-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1999-06-10 | — | — | WO | disclosed |