Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPC5 | Q9UL62 | 1/20 | 0.44 |
| ▸ | PDE1A | P54750 | 3/20 | 0.40 |
| ▸ | PDE1B | Q01064 | 3/20 | 0.40 |
| ▸ | PDE1C | Q14123 | 3/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | KDM4A | O75164 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 2/20 | 0.39 |
| ▸ | JAK1 | P23458 | 2/20 | 0.39 |
| ▸ | JAK3 | P52333 | 2/20 | 0.39 |
| ▸ | MTOR | P42345 | 6/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.39 |
| ▸ | GSK3A | P49840 | 1/20 | 0.39 |
| ▸ | NOX4 | Q9NPH5 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7476910 | 0.93 | KDM4E (0.41) | TRPC5PDE1APDE1BPDE1CHSD17B10 | |
| SCHEMBL5237590 | 0.81 | CYP1A2 (0.45) | HSD17B10KDM4EALDH1A1KDM4ALMNA | |
| SCHEMBL5237595 | 0.81 | CYP1A2 (0.45) | HSD17B10KDM4EALDH1A1KDM4ALMNA | |
| SCHEMBL7474494 | 0.81 | CYP1A2 (0.45) | HSD17B10KDM4EALDH1A1KDM4ALMNA | |
| SCHEMBL7480350 | 0.77 | GAA (0.37) | TRPC5HSD17B10KDM4EALDH1A1KDM4A | |
| SCHEMBL7477781 | 0.75 | KDM4E (0.47) | HSD17B10KDM4EALDH1A1KDM4ALMNA | |
| SCHEMBL7475545 | 0.73 | KDM4E (0.42) | HSD17B10KDM4EALDH1A1KDM4ALMNA | |
| SCHEMBL7478981 | 0.73 | KDM4E (0.42) | HSD17B10KDM4EALDH1A1KDM4ALMNA | |
| SCHEMBL7474802 | 0.73 | KDM4E (0.43) | HSD17B10KDM4EALDH1A1KDM4ALMNA | |
| SCHEMBL7476320 | 0.73 | KDM4E (0.42) | HSD17B10KDM4EALDH1A1KDM4ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0742218-B1 | PYRROLOPYRIDAZINE DERIVATIVE | SANKYO CO (JP) | 2002-12-04 | — | — | EP | disclosed |
| US-6063782-A | Pyrrolopyridazine derivatives | SANKYO COMPANY, LIMITED (JP) | 2000-05-16 | — | — | US | disclosed |
| EP-0742218-A1 | PYRROLOPYRIDAZINE DERIVATIVE | SANKYO COMPANY LIMITED (JP) | 1996-11-13 | — | — | EP | disclosed |