Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
| ▸ | CHEK1 | O14757 | 5/20 | 0.37 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.36 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.36 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.36 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 3/20 | 0.36 |
| ▸ | FLT3 | P36888 | 2/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | CSF1R | P07333 | 1/20 | 0.36 |
| ▸ | GSK3A | P49840 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.36 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.36 |
| ▸ | SLK | Q9H2G2 | 1/20 | 0.36 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.36 |
| ▸ | KIT | P10721 | 1/20 | 0.35 |
| ▸ | FLT4 | P35916 | 1/20 | 0.35 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5788234 | 1.00 | FFAR1 (0.38) | FFAR1CNR1CHEK1NR1H4SLC1A3 | |
| SCHEMBL6323523 | 0.87 | TDP1 (0.40) | KDRGSK3BTP53MAPTLMNA | |
| SCHEMBL4487044 | 0.85 | CES1 (0.39) | CHEK1KDRFLT3KITFLT4 | |
| SCHEMBL4491078 | 0.85 | BRD4 (0.38) | NR1H4AURKBCASP3 | |
| SCHEMBL4504086 | 0.84 | BACE1 (0.44) | CHEK1KDRFLT3TP53MAPT | |
| SCHEMBL3157920 | 0.84 | BACE1 (0.42) | FFAR1NR1H4TP53MAPTLMNA | |
| SCHEMBL5788238 | 0.83 | FFAR1 (0.43) | FFAR1CHEK1NR1H4SLC1A3SLC1A2 | |
| SCHEMBL5788243 | 0.83 | FFAR1 (0.43) | FFAR1CHEK1NR1H4SLC1A3SLC1A2 | |
| SCHEMBL5787703 | 0.82 | RXFP1 (0.49) | FFAR1TP53MAPTALDH1A1LMNA | |
| SCHEMBL5787702 | 0.82 | RXFP1 (0.49) | FFAR1TP53MAPTALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1212318-A1 | SUBSTITUTED INDOLINONES AS TYROSINE KINASE INHIBITORS | Boehringer Ingelheim Pharma KG (DE) | 2002-06-12 | — | — | EP | disclosed |
| WO-2001016130-A1 | SUBSTITUTED INDOLINONES AS TYROSINE KINASE INHIBITORS | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2001-03-08 | — | — | WO | disclosed |