Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 5/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 4/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | BRD2 | P25440 | 1/20 | 0.35 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.35 |
| ▸ | NAMPT | P43490 | 1/20 | 0.35 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.35 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.34 |
| ▸ | KIT | P10721 | 1/20 | 0.34 |
| ▸ | MARK3 | P27448 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | AKT1 | P31749 | 1/20 | 0.34 |
| ▸ | MARK2 | Q7KZI7 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6337430 | 1.00 | RET (0.41) | RETCHEK1EGFRAURKBAURKA | |
| SCHEMBL6337435 | 1.00 | RET (0.41) | RETCHEK1EGFRAURKBAURKA | |
| SCHEMBL6329081 | 0.94 | RET (0.42) | RETCHEK1EGFRAURKBAURKA | |
| SCHEMBL6329067 | 0.94 | RET (0.42) | RETCHEK1EGFRAURKBAURKA | |
| SCHEMBL6329095 | 0.90 | RET (0.44) | RETCHEK1EGFRBRD4BRD2 | |
| SCHEMBL6329107 | 0.90 | RET (0.44) | RETCHEK1EGFRBRD4BRD2 | |
| SCHEMBL6329638 | 0.88 | RET (0.40) | RETCHEK1EGFRAURKBAURKA | |
| SCHEMBL6329619 | 0.88 | RET (0.40) | RETCHEK1EGFRAURKBAURKA | |
| SCHEMBL6336920 | 0.87 | RET (0.43) | RETCHEK1EGFRAURKBKDR | |
| SCHEMBL6336916 | 0.87 | RET (0.43) | RETCHEK1EGFRAURKBKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1212318-A1 | SUBSTITUTED INDOLINONES AS TYROSINE KINASE INHIBITORS | Boehringer Ingelheim Pharma KG (DE) | 2002-06-12 | — | — | EP | disclosed |
| WO-2001016130-A1 | SUBSTITUTED INDOLINONES AS TYROSINE KINASE INHIBITORS | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2001-03-08 | — | — | WO | disclosed |