Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 17/20 | 0.62 |
| ▸ | HTR1B | P28222 | 14/20 | 0.62 |
| ▸ | HTR1A | P08908 | 2/20 | 0.62 |
| ▸ | HTR1F | P30939 | 2/20 | 0.62 |
| ▸ | APP | P05067 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | THPO | P40225 | 1/20 | 0.50 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.50 |
| ▸ | DRD2 | P14416 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7482982 | 0.89 | HTR1D (0.68) | HTR1DHTR1BHTR1AHTR1FCHRM2 | |
| SCHEMBL8383229 | 0.85 | SLC6A4 (0.56) | HTR1DHTR1BHTR1AHTR1FCHRM2 | |
| SCHEMBL7487991 | 0.81 | HTR1D (0.69) | HTR1DHTR1BHTR1AHTR1FAPP | |
| SCHEMBL7535628 | 0.81 | HTR1D (0.72) | HTR1DHTR1BHTR1AHTR1FAPP | |
| SCHEMBL7482621 | 0.80 | HTR1D (0.61) | HTR1DHTR1BHTR1AHTR1FAPP | |
| SCHEMBL7486818 | 0.79 | HTR1D (0.66) | HTR1DHTR1BHTR1AHTR1FAPP | |
| SCHEMBL7479251 | 0.79 | HTR1D (0.60) | HTR1DHTR1BHTR1AHTR1FAPP | |
| SCHEMBL7484191 | 0.79 | HTR1D (0.81) | HTR1DHTR1BHTR1AHTR1FCHRM2 | |
| SCHEMBL27496229 | 0.78 | HTR1D (0.73) | HTR1DHTR1BHTR1AHTR1FAPP | |
| SCHEMBL7485764 | 0.78 | SLC6A4 (0.63) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0733628-B9 | 5-Substituted-3-(1,2,3,6-tetrahydropyridin-4-yl)- and 3-(piperidin-4-yl)-1H-indoles: 5-HT1F agonists | LILLY CO ELI (US) | 2002-06-12 | — | — | EP | disclosed |
| EP-0733628-B1 | 5-Substituted-3-(1,2,3,6-tetrahydropyridin-4-yl)- and 3-(piperidin-4-yl)-1H-indoles: 5-HT1F agonists | LILLY CO ELI (US) | 2000-12-27 | — | — | EP | disclosed |
| US-5962474-A | ANALGESICS; HEADACHES | ELI LILLY AND COMPANY (US) | 1999-10-05 | — | — | US | disclosed |
| US-5708008-A | TREATMENT OF MIGRAINE | ELI LILLY AND COMPANY (US) | 1998-01-13 | — | — | US | disclosed |
| WO-1996029075-A1 | 5-SUBSTITUTED-3-(1,2,3,6-TETRAHYDROPYRIDIN-4-YL)- AND 3-(PIPERIDIN-4-YL)-1H-INDOLES: NEW 5-HT1F AGONISTS | ELI LILLY AND COMPANY (US) | 1996-09-26 | — | — | WO | disclosed |
| EP-0733628-A1 | 5-Substituted-3-(1,2,3,6-tetrahydropyridin-4-yl)- and 3-(piperidin-4-yl)-1h-indoles: new 5-ht1f agonists | ELI LILLY AND COMPANY (US) | 1996-09-25 | — | — | EP | disclosed |