Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.76 |
| ▸ | MEN1 | O00255 | 2/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.62 |
| ▸ | ATM | Q13315 | 2/20 | 0.62 |
| ▸ | RORC | P51449 | 1/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | LTA4H | P09960 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.50 |
| ▸ | HTR2A | P28223 | 1/20 | 0.50 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL321890 | 0.85 | HRH3 (0.78) | HRH3MEN1KMT2AATMRORC | |
| SCHEMBL3239820 | 0.85 | HRH3 (0.78) | HRH3MEN1KMT2AATMRORC | |
| SCHEMBL29056068 | 0.85 | HRH3 (0.78) | HRH3MEN1KMT2AATMRORC | |
| SCHEMBL8122521 | 0.85 | HRH3 (0.78) | HRH3MEN1KMT2AATMRORC | |
| Hydrochloric Acid SCHEMBL7599251 | 0.83 | HRH3 (0.88) | HRH3MEN1KMT2AATMRORC | |
| SCHEMBL3916831 | 0.83 | HRH3 (0.76) | HRH3MEN1KMT2AATMRORC | |
| SCHEMBL1927730 | 0.83 | HRH3 (0.76) | HRH3MEN1KMT2AATMRORC | |
| SCHEMBL1481137 | 0.83 | HRH3 (0.76) | HRH3MEN1KMT2AATMRORC | |
| SCHEMBL1943497 | 0.83 | HRH3 (0.75) | HRH3MEN1KMT2AATMCYP2D6 | |
| Water SCHEMBL27786097 | 0.82 | HRH3 (0.73) | HRH3MEN1KMT2AATMRORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1189609-A4 | CXCR-4 RECEPTOR ANTAGONISTS - THROMBOPOIETIN MIMETICS | SMITHKLINE BEECHAM CORP (US) | 2002-10-30 | — | — | EP | disclosed |
| EP-1189609-A1 | CXCR-4 RECEPTOR ANTAGONISTS - THROMBOPOIETIN MIMETICS | SMITHKLINE BEECHAM CORPORATION (US) | 2002-03-27 | — | — | EP | disclosed |
| WO-2000066112-A1 | CXCR-4 RECEPTOR ANTAGONISTS - THROMBOPOIETIN MIMETICS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-11-09 | — | — | WO | disclosed |