Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 16/20 | 0.55 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15798309 | 0.85 | CYP19A1 (0.61) | CYP19A1CYP3A4ALDH1A1 | |
| SCHEMBL9939642 | 0.83 | CYP19A1 (0.60) | CYP19A1CYP1B1CYP3A4 | |
| SCHEMBL1428474 | 0.82 | CYP19A1 (0.66) | CYP19A1CYP1B1CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL4448216 | 0.82 | CYP19A1 (0.61) | CYP19A1CYP1B1CYP3A4 | |
| SCHEMBL30604051 | 0.81 | CYP19A1 (0.53) | CYP19A1CYP1B1CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL30604053 | 0.81 | CYP19A1 (0.53) | CYP19A1CYP1B1CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL5493317 | 0.81 | CYP19A1 (0.60) | CYP19A1CYP1B1CYP3A4 | |
| SCHEMBL15846851 | 0.78 | CYP19A1 (0.49) | CYP19A1CYP1B1CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL30109409 | 0.78 | CYP19A1 (0.54) | CYP19A1CYP1B1CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL29561383 | 0.78 | CYP19A1 (0.56) | CYP19A1CYP1B1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0637203-B1 | REGULATION OF THE IMMUNE SYSTEM | LORIA ROGER (US) | 2002-08-21 | — | — | EP | disclosed |
| EP-1208842-A2 | Regulation of the immune system | LORIA, Roger (US) | 2002-05-29 | — | — | EP | disclosed |
| US-5641768-A | 5-androstene 3β, 17β diol for treatment | LORIA, ROGER M. | 1997-06-24 | — | — | US | disclosed |
| EP-0637203-A4 | REGULATION OF THE IMMUNE SYSTEM. | LORIA ROGER (US) | 1996-02-28 | — | — | EP | disclosed |
| US-5461042-A | Treatment with androstenediol or triol-type compounds to lessen the effects of chemotherapy and radiation | LORIA, ROGER M. | 1995-10-24 | — | — | US | disclosed |
| EP-0637203-A1 | REGULATION OF THE IMMUNE SYSTEM | LORIA, Roger (US) | 1995-02-08 | — | — | EP | disclosed |
| US-5277907-A | Lymphocyte proliferation-enhancing agent | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 1994-01-11 | — | — | US | disclosed |
| WO-1993020696-A1 | REGULATION OF THE IMMUNE SYSTEM | LORIA ROGER (US) | 1993-10-28 | — | — | WO | disclosed |
| US-5206008-A | Using androstene(diol or triol) | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 1993-04-27 | — | — | US | disclosed |