Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 4/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.34 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
| ▸ | HTR2B | P41595 | 1/20 | 0.33 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL715601 | 0.79 | SLC6A2 (0.39) | SLC6A2SLC6A3ADRB2HTR1AHTR2A | |
| SCHEMBL10511175 | 0.79 | SLC6A2 (0.39) | SLC6A2SLC6A3ADRB2HTR1AHTR2A | |
| SCHEMBL4315266 | 0.78 | SLC6A2 (0.39) | SLC6A2SLC6A3ADRB2HTR1AHTR2A | |
| SCHEMBL949891 | 0.78 | SLC6A2 (0.39) | SLC6A2SLC6A3ADRB2HTR1AHTR2A | |
| SCHEMBL947340 | 0.77 | SLC6A2 (0.38) | SLC6A2SLC6A3ADRB2HTR1AHTR2A | |
| SCHEMBL10510000 | 0.77 | HTR1D (0.40) | SLC6A2SLC6A3ADRB2HTR1AHTR2A | |
| Hydrochloric Acid SCHEMBL3938043 | 0.77 | SLC6A2 (0.38) | SLC6A2SLC6A3ADRB2HTR1AHTR2A | |
| SCHEMBL27521630 | 0.77 | SLC6A2 (0.34) | SLC6A2SLC6A3ADRB2HTR1AHTR2A | |
| Hydrochloric Acid SCHEMBL10512940 | 0.76 | SLC6A2 (0.39) | SLC6A2SLC6A3ADRB2HTR1AHTR2A | |
| Hydrochloric Acid SCHEMBL10513272 | 0.76 | SLC6A2 (0.37) | SLC6A2SLC6A3ADRB2HTR1AHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0858452-B1 | THIAZOLE DERIVATIVE AS PROTEIN KINASE C INHIBITORS | OTSUKA PHARMA CO LTD (JP) | 2002-03-13 | — | — | EP | disclosed |
| US-6140330-A | USEFUL AS PROTEIN KINASE INHIBITOR; FOR TREATMENT OF AUTOIMMUNE DISEASES SUCH AS RHEUMATOID ARTHRITIS, SYSTEMIC LUPUS ERYTHEMATOSUS, MULTIPLE SCLEROSIS, PSORIASIS, ETC., VARIOUS ALLERGIC DISEASES SUCH AS CROHN'S DISEASE, ASTHMA | OTSUKA PHARMACEUTICAL COMPANY, LIMITED (JP) | 2000-10-31 | — | — | US | disclosed |
| CN-1198160-A | Thiazole derivative | OTSUKA PHARMA CO LTD (JP) | 1998-11-04 | — | — | CN | disclosed |