Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 13/20 | 0.61 |
| ▸ | ABL1 | P00519 | 3/20 | 0.53 |
| ▸ | RAF1 | P04049 | 3/20 | 0.53 |
| ▸ | LYN | P07948 | 3/20 | 0.53 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.53 |
| ▸ | EGFR | P00533 | 2/20 | 0.53 |
| ▸ | BRAF | P15056 | 2/20 | 0.53 |
| ▸ | EPHA2 | P29317 | 2/20 | 0.53 |
| ▸ | EPHA3 | P29320 | 2/20 | 0.53 |
| ▸ | AKT1 | P31749 | 1/20 | 0.53 |
| ▸ | SRC | P12931 | 2/20 | 0.51 |
| ▸ | TNF | P01375 | 4/20 | 0.41 |
| ▸ | MAPK13 | O15264 | 3/20 | 0.41 |
| ▸ | MAPK12 | P53778 | 3/20 | 0.41 |
| ▸ | MAPK11 | Q15759 | 3/20 | 0.41 |
| ▸ | CIT | O14578 | 1/20 | 0.41 |
| ▸ | MUSK | O15146 | 1/20 | 0.41 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.41 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.41 |
| ▸ | STK10 | O94804 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4091873 | 0.85 | MAPK14 (0.81) | MAPK14ABL1RAF1LYNMAPK9 | |
| SCHEMBL4086203 | 0.82 | MAPK14 (0.64) | MAPK14ABL1RAF1LYNMAPK9 | |
| SCHEMBL27580655 | 0.80 | MAPK14 (0.57) | MAPK14ABL1RAF1LYNMAPK9 | |
| SCHEMBL4096572 | 0.79 | MAPK14 (0.57) | MAPK14ABL1RAF1LYNMAPK9 | |
| SCHEMBL4085454 | 0.78 | MAPK14 (0.82) | MAPK14ABL1RAF1LYNMAPK9 | |
| SCHEMBL4087842 | 0.78 | MAPK14 (0.79) | MAPK14ABL1RAF1LYNMAPK9 | |
| SCHEMBL4098327 | 0.77 | MAPK14 (0.81) | MAPK14ABL1RAF1LYNMAPK9 | |
| SCHEMBL4091678 | 0.77 | MAPK14 (0.81) | MAPK14ABL1RAF1LYNMAPK9 | |
| SCHEMBL4082089 | 0.77 | MAPK14 (0.77) | MAPK14ABL1RAF1LYNMAPK9 | |
| SCHEMBL4092806 | 0.77 | MAPK14 (0.80) | MAPK14ABL1RAF1LYNMAPK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1165516-A2 | HETEROCYCLIC UREA AND RELATED COMPOUNDS USEFUL AS ANTI-INFLAMMATORY AGENTS | BOEHRINGER INGELHEIM PHARMACEUTICALS INC. (US) | 2002-01-02 | — | — | EP | disclosed |
| WO-2000055139-A2 | HETEROCYCLIC UREA AND RELATED COMPOUNDS USEFUL AS ANTI-INFLAMMATORY AGENTS | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2000-09-21 | — | — | WO | disclosed |