SCHEMBL7475745

SCHEMBL7475745

C=C(C)Cn1c(C)c(C)c2cnnc(OCc3ccccc3)c21

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2C9 P11712 2/20 0.52
CYP2C19 P33261 2/20 0.52
CYP1A2 P05177 1/20 0.52
CYP3A4 P08684 1/20 0.52
CYP2D6 P10635 1/20 0.52
L3MBTL1 Q9Y468 3/20 0.35
MAPT P10636 4/20 0.35
TSHR P16473 3/20 0.34
LMNA P02545 3/20 0.34
HSD17B10 Q99714 1/20 0.34
GABRA1 P14867 2/20 0.34
GABRG2 P18507 2/20 0.34
GABRB3 P28472 2/20 0.34
GABRA5 P31644 2/20 0.34
GABRA3 P34903 2/20 0.34
GABRA2 P47869 2/20 0.34
ALDH1A1 P00352 3/20 0.34
MAPK1 P28482 2/20 0.34
HTT P42858 2/20 0.34
HPGD P15428 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7483202 0.90 CYP1A2 (0.53) CYP2C9CYP2C19CYP1A2CYP3A4CYP2D6
SCHEMBL7484153 0.89 CYP1A2 (0.66) CYP2C9CYP2C19CYP1A2CYP3A4CYP2D6
SCHEMBL7486320 0.85 CYP1A2 (0.55) CYP2C9CYP2C19CYP1A2CYP3A4CYP2D6
SCHEMBL7486325 0.85 CYP1A2 (0.55) CYP2C9CYP2C19CYP1A2CYP3A4CYP2D6
SCHEMBL7480160 0.83 CYP2C9 (0.51) CYP2C9CYP2C19CYP1A2CYP3A4CYP2D6
SCHEMBL7480602 0.83 CYP1A2 (0.53) CYP2C9CYP2C19CYP1A2CYP3A4CYP2D6
SCHEMBL7487573 0.83 CYP1A2 (0.57) CYP2C9CYP2C19CYP1A2CYP3A4CYP2D6
SCHEMBL7485341 0.81 CYP1A2 (0.58) CYP2C9CYP2C19CYP1A2CYP3A4CYP2D6
SCHEMBL7482125 0.81 CYP1A2 (0.53) CYP2C9CYP2C19CYP1A2CYP3A4CYP2D6
SCHEMBL7482910 0.81 CYP1A2 (0.55) CYP2C9CYP2C19CYP1A2CYP3A4CYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0742218-B1 PYRROLOPYRIDAZINE DERIVATIVE SANKYO CO (JP) 2002-12-04 EP claimed
US-6063782-A Pyrrolopyridazine derivatives SANKYO COMPANY, LIMITED (JP) 2000-05-16 US claimed
CN-1143964-A Pyrrolopyridazine derivative SANKYO CO (JP) 1997-02-26 CN claimed
EP-0742218-A1 PYRROLOPYRIDAZINE DERIVATIVE SANKYO COMPANY LIMITED (JP) 1996-11-13 EP claimed
EP-0742218-B1 PYRROLOPYRIDAZINE DERIVATIVE SANKYO CO (JP) 2002-12-04 EP disclosed
US-6063782-A Pyrrolopyridazine derivatives SANKYO COMPANY, LIMITED (JP) 2000-05-16 US disclosed
CN-1143964-A Pyrrolopyridazine derivative SANKYO CO (JP) 1997-02-26 CN disclosed
EP-0742218-A1 PYRROLOPYRIDAZINE DERIVATIVE SANKYO COMPANY LIMITED (JP) 1996-11-13 EP disclosed