Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 4/20 | 0.44 |
| ▸ | BRD4 | O60885 | 10/20 | 0.38 |
| ▸ | BRD2 | P25440 | 2/20 | 0.38 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | BCHE | P06276 | 2/20 | 0.34 |
| ▸ | ACHE | P22303 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6340151 | 1.00 | RET (0.44) | RETBRD4BRD2PDPK1EGFR | |
| SCHEMBL6336774 | 0.89 | RET (0.42) | RETBRD4BRD2PDPK1EGFR | |
| SCHEMBL5781655 | 0.87 | RET (0.44) | RETBRD4BRD2EGFRCHEK1 | |
| SCHEMBL6333465 | 0.87 | RET (0.41) | RETBRD4BRD2PDPK1EGFR | |
| SCHEMBL6337186 | 0.86 | RET (0.43) | RETBRD4BRD2PDPK1EGFR | |
| SCHEMBL6333341 | 0.85 | RET (0.54) | RETBRD4BRD2EGFRCHEK1 | |
| SCHEMBL6333335 | 0.85 | RET (0.54) | RETBRD4BRD2EGFRCHEK1 | |
| SCHEMBL6329674 | 0.84 | RET (0.48) | RETBRD4BRD2EGFRBCHE | |
| SCHEMBL6329682 | 0.84 | RET (0.48) | RETBRD4BRD2EGFRBCHE | |
| SCHEMBL6338806 | 0.83 | RET (0.41) | RETBRD4BRD2PDPK1EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1212318-A1 | SUBSTITUTED INDOLINONES AS TYROSINE KINASE INHIBITORS | Boehringer Ingelheim Pharma KG (DE) | 2002-06-12 | — | — | EP | disclosed |
| WO-2001016130-A1 | SUBSTITUTED INDOLINONES AS TYROSINE KINASE INHIBITORS | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2001-03-08 | — | — | WO | disclosed |