Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 20/20 | 0.79 |
| ▸ | HTR1B | P28222 | 20/20 | 0.79 |
| ▸ | HTR1A | P08908 | 1/20 | 0.67 |
| ▸ | HTR2A | P28223 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7475880 | 0.95 | HTR1D (0.83) | HTR1DHTR1B | |
| SCHEMBL7471633 | 0.92 | HTR1D (0.76) | HTR1DHTR1BHTR1AHTR2A | |
| SCHEMBL7479750 | 0.90 | HTR1D (0.81) | HTR1DHTR1BHTR2A | |
| SCHEMBL7473309 | 0.89 | HTR1D (0.72) | HTR1DHTR1BHTR2A | |
| SCHEMBL7479048 | 0.88 | HTR1D (1.00) | HTR1DHTR1BHTR2A | |
| SCHEMBL7481234 | 0.88 | HTR1D (0.80) | HTR1DHTR1B | |
| SCHEMBL7476231 | 0.88 | HTR1D (0.80) | HTR1DHTR1BHTR2A | |
| SCHEMBL7474485 | 0.86 | HTR1D (0.67) | HTR1DHTR1B | |
| Oxalic Acid SCHEMBL8662945 | 0.84 | HTR1D (0.91) | HTR1DHTR1B | |
| SCHEMBL7478570 | 0.84 | HTR1D (0.63) | HTR1DHTR1BHTR1AHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0925302-B1 | PALLADIUM CATALYZED INDOLIZATION | MERCK & CO INC (US) | 2002-11-20 | — | — | EP | claimed |
| US-5808064-A | HYDROSILATION OF AN INDOLE AS CHEMICAL INTERMEDIATE | MERCK & CO., INC. (US) | 1998-09-15 | — | — | US | claimed |
| EP-0861245-A1 | PIPERIDINE AND TETRAHYDROPYRIDINE DERIVATIVES | MERCK SHARP & DOHME LTD. (GB) | 1998-09-02 | — | — | EP | claimed |
| WO-1997019073-A1 | PIPERIDINE AND TETRAHYDROPYRIDINE DERIVATIVES | MERCK SHARP & DOHME LIMITED (GB) | 1997-05-29 | — | — | WO | claimed |
| EP-0925302-B1 | PALLADIUM CATALYZED INDOLIZATION | MERCK & CO INC (US) | 2002-11-20 | — | — | EP | disclosed |
| US-5973156-A | Piperidine and tetrahydropyridine derivatives | MERCK SHARP & DOME LTD. (GB) | 1999-10-26 | — | — | US | disclosed |
| US-5808064-A | HYDROSILATION OF AN INDOLE AS CHEMICAL INTERMEDIATE | MERCK & CO., INC. (US) | 1998-09-15 | — | — | US | disclosed |