Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ORAI1 | Q96D31 | 5/20 | 0.55 |
| ▸ | TRPC3 | Q13507 | 3/20 | 0.53 |
| ▸ | TP53 | P04637 | 2/20 | 0.53 |
| ▸ | TRPC5 | Q9UL62 | 1/20 | 0.53 |
| ▸ | TRPC1 | P48995 | 1/20 | 0.52 |
| ▸ | STIM1 | Q13586 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | CRACR2A | Q9BSW2 | 4/20 | 0.43 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7323920 | 0.85 | ORAI1 (0.60) | ORAI1TRPC3TP53TRPC5TRPC1 | |
| SCHEMBL7320587 | 0.83 | ORAI1 (0.64) | ORAI1TRPC3TP53TRPC5TRPC1 | |
| SCHEMBL7327028 | 0.83 | ORAI1 (0.57) | ORAI1TRPC3TP53TRPC5TRPC1 | |
| SCHEMBL7316026 | 0.82 | ORAI1 (0.56) | ORAI1TRPC3TP53TRPC5TRPC1 | |
| SCHEMBL7325234 | 0.79 | ORAI1 (0.67) | ORAI1TRPC3TP53TRPC5TRPC1 | |
| SCHEMBL7322281 | 0.79 | ORAI1 (0.51) | ORAI1TRPC3TP53TRPC5TRPC1 | |
| SCHEMBL7326587 | 0.79 | ORAI1 (0.55) | ORAI1TRPC3TP53TRPC5TRPC1 | |
| SCHEMBL7319204 | 0.78 | ORAI1 (0.60) | ORAI1TRPC3TP53TRPC5TRPC1 | |
| SCHEMBL7323936 | 0.78 | ORAI1 (0.59) | ORAI1TRPC3TP53TRPC5TRPC1 | |
| SCHEMBL7318836 | 0.77 | ORAI1 (0.49) | ORAI1TRPC3TP53TRPC5TRPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1068187-A1 | PYRAZOLE INHIBITORS OF CYTOKINE PRODUCTION | ABBOTT LABORATORIES (US) | 2001-01-17 | — | — | EP | disclosed |
| WO-1999051580-A1 | PYRAZOLE INHIBITORS OF CYTOKINE PRODUCTION | ABBOTT LABORATORIES (US) | 1999-10-14 | — | — | WO | disclosed |