Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.67 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.67 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.67 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.67 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.37 |
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 3/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7472617 | 0.89 | CYP1A2 (0.53) | CYP1A2CYP3A4CYP2C9CYP2D6CYP2C19 | |
| SCHEMBL7480602 | 0.89 | CYP1A2 (0.53) | CYP1A2CYP3A4CYP2C9CYP2D6CYP2C19 | |
| SCHEMBL7483147 | 0.89 | CYP1A2 (0.53) | CYP1A2CYP3A4CYP2C9CYP2D6CYP2C19 | |
| SCHEMBL7484834 | 0.88 | CYP1A2 (0.66) | CYP1A2CYP3A4CYP2C9CYP2D6CYP2C19 | |
| SCHEMBL7474364 | 0.88 | CYP1A2 (0.66) | CYP1A2CYP3A4CYP2C9CYP2D6CYP2C19 | |
| SCHEMBL7484831 | 0.88 | CYP1A2 (0.66) | CYP1A2CYP3A4CYP2C9CYP2D6CYP2C19 | |
| SCHEMBL7474369 | 0.88 | CYP1A2 (0.66) | CYP1A2CYP3A4CYP2C9CYP2D6CYP2C19 | |
| SCHEMBL7478848 | 0.88 | CYP1A2 (0.52) | CYP1A2CYP3A4CYP2C9CYP2D6CYP2C19 | |
| Hydrochloric Acid SCHEMBL7482118 | 0.87 | CYP1A2 (0.64) | CYP1A2CYP3A4CYP2C9CYP2D6CYP2C19 | |
| Hydrochloric Acid SCHEMBL7482124 | 0.87 | CYP1A2 (0.64) | CYP1A2CYP3A4CYP2C9CYP2D6CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0742218-B1 | PYRROLOPYRIDAZINE DERIVATIVE | SANKYO CO (JP) | 2002-12-04 | — | — | EP | claimed |
| US-6063782-A | Pyrrolopyridazine derivatives | SANKYO COMPANY, LIMITED (JP) | 2000-05-16 | — | — | US | claimed |
| EP-0742218-A1 | PYRROLOPYRIDAZINE DERIVATIVE | SANKYO COMPANY LIMITED (JP) | 1996-11-13 | — | — | EP | claimed |
| EP-0742218-B1 | PYRROLOPYRIDAZINE DERIVATIVE | SANKYO CO (JP) | 2002-12-04 | — | — | EP | disclosed |
| US-6063782-A | Pyrrolopyridazine derivatives | SANKYO COMPANY, LIMITED (JP) | 2000-05-16 | — | — | US | disclosed |
| EP-0742218-A1 | PYRROLOPYRIDAZINE DERIVATIVE | SANKYO COMPANY LIMITED (JP) | 1996-11-13 | — | — | EP | disclosed |