Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 4/20 | 0.51 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | BRD4 | O60885 | 3/20 | 0.41 |
| ▸ | BRD2 | P25440 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | CDYL2 | Q8N8U2 | 1/20 | 0.38 |
| ▸ | CDYL | Q9Y232 | 1/20 | 0.38 |
| ▸ | CDY1; CDY1B | Q9Y6F8 | 1/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.38 |
| ▸ | TLK2 | Q86UE8 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5783036 | 1.00 | RET (0.51) | RETATMBRD4BRD2MEN1 | |
| SCHEMBL6330717 | 1.00 | RET (0.51) | RETATMBRD4BRD2MEN1 | |
| SCHEMBL5789112 | 0.92 | RET (0.55) | RETBRD4BRD2MEN1KMT2A | |
| SCHEMBL5789109 | 0.92 | RET (0.55) | RETBRD4BRD2MEN1KMT2A | |
| SCHEMBL5784002 | 0.90 | RET (0.52) | RETBRD4BRD2MEN1KMT2A | |
| SCHEMBL5785525 | 0.90 | RET (0.52) | RETBRD4BRD2MEN1KMT2A | |
| SCHEMBL5785496 | 0.90 | RET (0.54) | RETBRD4BRD2MEN1KMT2A | |
| SCHEMBL5785531 | 0.90 | RET (0.52) | RETBRD4BRD2MEN1KMT2A | |
| SCHEMBL5785488 | 0.90 | RET (0.54) | RETBRD4BRD2MEN1KMT2A | |
| SCHEMBL6330841 | 0.90 | RET (0.52) | RETBRD4BRD2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1212318-A1 | SUBSTITUTED INDOLINONES AS TYROSINE KINASE INHIBITORS | Boehringer Ingelheim Pharma KG (DE) | 2002-06-12 | — | — | EP | disclosed |
| WO-2001016130-A1 | SUBSTITUTED INDOLINONES AS TYROSINE KINASE INHIBITORS | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2001-03-08 | — | — | WO | disclosed |